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. 2023 Sep 19;13(18):2964.
doi: 10.3390/ani13182964.

Genome-Wide Association Studies for Body Conformation Traits in Korean Holstein Population

Md Azizul Haque  1 , Mohammad Zahangir Alam  1 , Asif Iqbal  1 , Yun-Mi Lee  1 , Chang-Gwon Dang  2 , Jong-Joo Kim  1
Affiliations

Genome-Wide Association Studies for Body Conformation Traits in Korean Holstein Population

Md Azizul Haque et al. Animals (Basel). .

Abstract

The objective of this study was to identify quantitative trait loci (QTL) and nearby candidate genes that influence body conformation traits. Phenotypic data for 24 body conformation traits were collected from a population of 2329 Korean Holstein cattle, and all animals were genotyped using the 50 K Illumina bovine SNP chip. A total of 24 genome-wide significant SNPs associated with 24 body conformation traits were identified by genome-wide association analysis. The selection of the most promising candidate genes was based on gene ontology (GO) terms and the previously identified functions that influence various body conformation traits as determined in our study. These genes include KCNA1, RYBP, PTH1R, TMIE, and GNAI3 for body traits; ANGPT1 for rump traits; MALRD1, INHBA, and HOXA13 for feet and leg traits; and CDK1, RHOBTB1, and SLC17A1 for udder traits, respectively. These findings contribute to our understanding of the genetic basis of body conformation traits in this population and pave the way for future breeding strategies aimed at enhancing desirable traits in dairy cattle.

Keywords: Korean Holstein; body conformation traits; candidate gene; genome-wide association study.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Significant GO terms (biological process, cellular component, and molecular function) and KEGG pathways of candidate genes associated with body conformation traits.
See this image and copyright information in PMC

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