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. 2023 Sep 6;15(18):4447.
doi: 10.3390/cancers15184447.

Quality of Life, Clinical, and Patient-Reported Outcomes after Pencil Beam Scanning Proton Therapy Delivered for Intracranial Grade WHO 1-2 Meningioma in Children and Adolescents

Marta García-Marqueta  1 , Miriam Vázquez  1 , Reinhardt Krcek  1   2 , Ulrike L Kliebsch  1 , Katja Baust  3 , Dominic Leiser  1 , Michelle van Heerden  1 , Alessia Pica  1 , Gabriele Calaminus  3 , Damien C Weber  1   2   4
Affiliations

Quality of Life, Clinical, and Patient-Reported Outcomes after Pencil Beam Scanning Proton Therapy Delivered for Intracranial Grade WHO 1-2 Meningioma in Children and Adolescents

Marta García-Marqueta et al. Cancers (Basel). .

Abstract

Purpose: The purpose of this study was to report the clinical and patient-reported outcomes of children and adolescents with intracranial meningioma treated with pencil beam scanning proton therapy (PBS-PT).

Material and methods: Out of a total cohort of 207 intracranial meningioma patients treated with PBS-PT between 1999 and 2022, 10 (4.8%) were children or adolescents aged < 18 years. Median age was 13.9 years (range, 3.2-17.2). Six (60%) children were treated as primary treatment (postoperative PT, n = 4; exclusive PT, n = 2) and four (40%) at the time of tumor recurrence. Acute and late toxicities were registered according to Common Terminology Criteria of Adverse Events (CTCAE). Quality of life (QoL) before PBS-PT was assessed using PEDQOL questionnaires. Educational, functional, and social aspects after PT were assessed through our in-house developed follow-up surveys. Median follow-up time was 71.1 months (range, 2.5-249.7), and median time to last questionnaire available was 37.6 months (range, 5.75-112.6).

Results: Five (50%) children developed local failure (LF) at a median time of 32.4 months (range, 17.7-55.4) after PBS-PT and four (80%) were considered in-field. One patient died of T-cell lymphoma 127.1 months after PBS-PT. Estimated 5-year local control (LC) and overall survival (OS) rates were 19.4% and 100.0%, respectively. Except for one patient who developed a cataract requiring surgery, no grade ≥3 late toxicities were reported. Before PT, patients rated their QoL lower than their parents in most domains. During the first year after PT, one child required educational support, one needed to attend to a special school, one had social problems and another three children required assistance for daily basic activities (DBA). Three years after PT, only one child required assistance for DBA.

Conclusions: The outcome of children with intracranial meningioma treated with PBS-PT is in line with other centers who have reported results of radiation therapy delivered to this particular patient group. This therapy provides acceptable functional status profiles with no high-grade adverse radiation-induced events.

Keywords: adolescents; children; intracranial meningioma; patient-reported outcomes; pencil beam scanning; proton therapy; quality of life; teenagers.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Parents (Elt) and patients (Pat) reported quality of life scores before proton therapy (PEDQOL, E1).
Figure 2
Figure 2
Patient reported outcomes based on in-house questionnaires for evaluating functional status during the 1st year and 2 and 3 years after PBS-PT.
See this image and copyright information in PMC

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References

    1. Ostrom Q.T., Cioffi G., Gittleman H., Patil N., Waite K., Kruchko C., Barnholtz-Sloan J.S. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012–2016. Neuro Oncol. 2019;21:V1–V100. doi: 10.1093/neuonc/noz150. - DOI - PMC - PubMed
    1. Ostrom Q.T., De Blank P.M., Kruchko C., Petersen C.M., Liao P., Finlay J.L., Stearns D.S., Wolff J.E., Wolinsky Y., Letterio J.J., et al. Alex’s Lemonade Stand Foundation Infant and Childhood Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2007–2011. Neuro Oncol. 2014;16:x1–x35. doi: 10.1093/neuonc/nou223. - DOI - PMC - PubMed
    1. Ostrom Q.T., Gittleman H., De Blank P.M., Finlay J.L., Gurney J.G., McKean-Cowdin R., Stearns D.S., Wolff J.E., Liu M., Wolinsky Y., et al. American Brain Tumor Association Adolescent and Young Adult Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008–2012. Neuro Oncol. 2015;18:i1–i50. doi: 10.1093/neuonc/nov297. - DOI - PMC - PubMed
    1. Toland A., McNulty S.N., Pekmezci M., Evenson M., Huntoon K., Pierson C.R., Boue D.R., Perry A., Dahiya S. Pediatric Meningioma: A Clinicopathologic and Molecular Study with Potential Grading Implications. Brain Pathol. 2020;30:1134–1143. doi: 10.1111/bpa.12884. - DOI - PMC - PubMed
    1. Kirches E., Sahm F., Korshunov A., Bluecher C., Waldt N., Kropf S., Schrimpf D., Sievers P., Stichel D., Schüller U., et al. Molecular Profiling of Pediatric Meningiomas Shows Tumor Characteristics Distinct from Adult Meningiomas. Acta Neuropathol. 2021;142:873–886. doi: 10.1007/s00401-021-02351-x. - DOI - PMC - PubMed