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Review
. 2023 Aug 31;11(9):2437.
doi: 10.3390/biomedicines11092437.

Biomarkers for Kidney-Transplant Rejection: A Short Review Study

Israa Sharaby  1 , Ahmed Alksas  1 , Mohamed Abou El-Ghar  2 , Mona Eldeeb  2 , Mohammed Ghazal  3 , Dibson Gondim  4 , Ayman El-Baz  1
Affiliations
Review

Biomarkers for Kidney-Transplant Rejection: A Short Review Study

Israa Sharaby et al. Biomedicines. .

Abstract

Kidney transplantation is the preferred treatment for end-stage renal failure, but the limited availability of donors and the risk of immune rejection pose significant challenges. Early detection of acute renal rejection is a critical step to increasing the lifespan of the transplanted kidney. Investigating the clinical, genetic, and histopathological markers correlated to acute renal rejection, as well as finding noninvasive markers for early detection, is urgently needed. It is also crucial to identify which markers are associated with different types of acute renal rejection to manage treatment effectively. This short review summarizes recent studies that investigated various markers, including genomics, histopathology, and clinical markers, to differentiate between different types of acute kidney rejection. Our review identifies the markers that can aid in the early detection of acute renal rejection, potentially leading to better treatment and prognosis for renal-transplant patients.

Keywords: acute-mediated rejection (AMR); biomarkers; histopathological markers; kidney-transplant rejection; renal rejection.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A brief overview of different markers utilized in the early identification of acute renal rejection.
See this image and copyright information in PMC

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