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Review
. 2023 Sep 5;11(9):2465.
doi: 10.3390/biomedicines11092465.

Which Comes First, Nonalcoholic Fatty Liver Disease or Arterial Hypertension?

Julia A Golubeva  1 , Anna F Sheptulina  1   2 , Anastasia Yu Elkina  1   3 , Ekaterina O Liusina  1 , Anton R Kiselev  4 , Oxana M Drapkina  1   2
Affiliations
Review

Which Comes First, Nonalcoholic Fatty Liver Disease or Arterial Hypertension?

Julia A Golubeva et al. Biomedicines. .

Abstract

Non-alcoholic fatty liver disease (NAFLD) and arterial hypertension (AH) are widespread noncommunicable diseases in the global population. Since hypertension and NAFLD are diseases associated with metabolic syndrome, they are often comorbid. In fact, many contemporary published studies confirm the association of these diseases with each other, regardless of whether other metabolic factors, such as obesity, dyslipidemia, and type 2 diabetes mellites, are present. This narrative review considers the features of the association between NAFLD and AH, as well as possible pathophysiological mechanisms.

Keywords: hypertension; non-alcoholic fatty liver disease; steatohepatitis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Common pathophysiological links underlining the association between arterial hypertension and non-alcoholic fatty liver disease. See text for explanations. NAFLD = non-alcoholic fatty liver disease; RAAS = renin-angiotensin-aldosterone system; SNS = sympathetic nervous system.
See this image and copyright information in PMC

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