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Review
. 2023 Sep 12;11(9):2519.
doi: 10.3390/biomedicines11092519.

Signaling Roleplay between Ion Channels during Mammalian Sperm Capacitation

Filip Benko  1 , Dana Urminská  1 , Michal Ďuračka  2 , Eva Tvrdá  1
Affiliations
Review

Signaling Roleplay between Ion Channels during Mammalian Sperm Capacitation

Filip Benko et al. Biomedicines. .

Abstract

In order to accomplish their primary goal, mammalian spermatozoa must undergo a series of physiological, biochemical, and functional changes crucial for the acquisition of fertilization ability. Spermatozoa are highly polarized cells, which must swiftly respond to ionic changes on their passage through the female reproductive tract, and which are necessary for male gametes to acquire their functional competence. This review summarizes the current knowledge about specific ion channels and transporters located in the mammalian sperm plasma membrane, which are intricately involved in the initiation of changes within the ionic milieu of the sperm cell, leading to variations in the sperm membrane potential, membrane depolarization and hyperpolarization, changes in sperm motility and capacitation to further lead to the acrosome reaction and sperm-egg fusion. We also discuss the functionality of selected ion channels in male reproductive health and/or disease since these may become promising targets for clinical management of infertility in the future.

Keywords: acrosome reaction; capacitation; hyperpolarization; ion channels; spermatozoa.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Ion channels of spermatozoa. Created with BioRender.com (Toronto, ON, Canada, https://app.biorender.com/).
See this image and copyright information in PMC

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References

    1. Gogoi J., Mondal M., Pal P., Upadhyay V.R., Kuri P., Mukherjee I., Tripura S. Potential role of CatSper and proton ion channels in bull fertility. Pharma Innov. 2022;11:313–321.
    1. Delgado-Bermúdez A., Yeste M., Bonet S., Pinart E. A review on the role of Bicarbonate and Proton Transporters during Sperm Capacitation in Mammals. Int. J. Mol. Sci. 2022;23:6333. doi: 10.3390/ijms23116333. - DOI - PMC - PubMed
    1. Matamoros-Volante A., Treviño C.L. Capacitation-associated alkalization in human sperm is differentially controlled at the subcellular level. J. Cell Sci. 2020;133:jcs238816. doi: 10.1242/jcs.238816. - DOI - PubMed
    1. López-González I., Torres-Rodríguez P., Sánchez-Carranza O., Solís-López A., Santi C.M., Darzson A., Treviño C.L. Membrane hyperpolarization during human sperm capacitation. Mol. Hum. Reprod. 2014;20:619–629. doi: 10.1093/molehr/gau029. - DOI - PMC - PubMed
    1. Baro Graf C., Ritagliati C., Stival C., Balestrini P.A., Buffone M.G., Krapf D. Determination of a robust assay for human sperm membrane potential analysis. Front. Cell Develop. Biol. 2019;7:101. doi: 10.3389/fcell.2019.00101. - DOI - PMC - PubMed

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