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Review
. 2023 Sep 10;13(18):2898.
doi: 10.3390/diagnostics13182898.

Sleep Disorders Associated with Neurodegenerative Diseases

Lucreția Anghel  1   2 , Anamaria Ciubară  1 , Aurel Nechita  1   3 , Luiza Nechita  1   2 , Corina Manole  1   2 , Liliana Baroiu  1   4 , Alexandru Bogdan Ciubară  5 , Carmina Liana Mușat  2   5
Affiliations
Review

Sleep Disorders Associated with Neurodegenerative Diseases

Lucreția Anghel et al. Diagnostics (Basel). .

Abstract

Sleep disturbances are common in various neurological pathologies, including amyotrophic lateral sclerosis (ALS), multiple system atrophy (MSA), hereditary ataxias, Huntington's disease (HD), progressive supranuclear palsy (PSP), and dementia with Lewy bodies (DLB). This article reviews the prevalence and characteristics of sleep disorders in these conditions, highlighting their impact on patients' quality of life and disease progression. Sleep-related breathing disorders, insomnia, restless legs syndrome (RLS), periodic limb movement syndrome (PLMS), and rapid eye movement sleep behavior disorder (RBD) are among the common sleep disturbances reported. Both pharmacological and non-pharmacological interventions play crucial roles in managing sleep disturbances and enhancing overall patient care.

Keywords: Huntington’s disease (HD); amyotrophic lateral sclerosis (ALS); hereditary ataxias; insomnia; multiple system atrophy (MSA); neurological pathologies; sleep disturbances; sleep-related breathing disorders.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The anatomy of sleep.
See this image and copyright information in PMC

References

    1. Gao H.-M., Hong J.-S. Why Neurodegenerative Diseases Are Progressive: Uncontrolled Inflammation Drives Disease Progression. Trends Immunol. 2008;29:357–365. doi: 10.1016/j.it.2008.05.002. - DOI - PMC - PubMed
    1. Wennberg A., Wu M. Sleep Disturbance, Cognitive Decline, and Dementia: A Review. Semin. Neurol. 2017;37:395–406. doi: 10.1055/s-0037-1604351. - DOI - PMC - PubMed
    1. Sutton E.L. Insomnia. Ann. Intern. Med. 2021;174:ITC33–ITC48. doi: 10.7326/AITC202103160. - DOI - PubMed
    1. Herrero Babiloni A., Baril A.-A. The Putative Role of Neuroinflammation in the Interaction between Traumatic Brain Injuries, Sleep, Pain and Other Neuropsychiatric Outcomes: A State-of-the-Art Review. J. Clin. Med. 2023;12:1793. doi: 10.3390/jcm12051793. - DOI - PMC - PubMed
    1. Eban-Rothschild A., Appelbaum L. Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive. Neuropsychopharmacology. 2018;43:937–952. doi: 10.1038/npp.2017.294. - DOI - PMC - PubMed

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