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. 2023 Sep 8;11(18):2502.
doi: 10.3390/healthcare11182502.

Economic Evaluation of Glucosamine in Knee Osteoarthritis Treatments in Vietnam

Nam Xuan Vo  1 , Uyen Thi Thuc Che  1 , Thanh Thi Thanh Ngo  1 , Tien Thuy Bui  2
Affiliations

Economic Evaluation of Glucosamine in Knee Osteoarthritis Treatments in Vietnam

Nam Xuan Vo et al. Healthcare (Basel). .

Abstract

Osteoarthritis (OA) is the degeneration of cartilage in joints that results in bones rubbing against each other; it causes uncomfortable symptoms such as pain, swelling, and stiffness and can lead to disability. It usually occurs in the elderly and causes a large medical burden. The aim of this study is to evaluate the cost-effectiveness between the standard treatment for osteoarthritis and standard treatment with added crystalline glucosamine sulfate at various stages. Markov analysis modeling was applied to evaluate the effect of both adding glucosamine compared to standard treatment from a societal perspective during whole patients' lifetimes. Data input was collected from reviews in previous studies. The outcome was measured in quality-adjusted life years (QALYs), and the Incremental Cost-Effectiveness Ratio (ICER) from a societal perspective was applied with 3% and discounted for all costs and outcomes. One-way analysis via the Tornado diagram was performed to investigate the change in factors in the model. In general, adding glucosamine into the standard treatment proved to be more cost-effective compared to the standard treatment. Particularly, the early-stage addition of glucosamine in the treatment was cost-effective compared to the post-stage addition of glucosamine. The addition of supplementing crystalline glucosamine sulfate to the whole regimen at any stage was cost-effective at the willingness-to-pay (WTP) threshold.

Keywords: Vietnam; cost-utility analysis; economic evaluation; glucosamine; knee osteoarthritis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Model structure.
Figure 2
Figure 2
Tornado diagram of ICER change in different regimens when glucosamine was added before NSAIDs use.
Figure 3
Figure 3
Tornado diagram of ICER change in different regimens when glucosamine was added after NSAIDs use.
Figure 3
Figure 3
Tornado diagram of ICER change in different regimens when glucosamine was added after NSAIDs use.
See this image and copyright information in PMC

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