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Review
. 2023 Sep 20;24(18):14351.
doi: 10.3390/ijms241814351.

Exploring the Potential of Proteome Analysis as a Promising Tool for Evaluation of Sudden Cardiac Death (SCD) in Forensic Settings: A Literature Review

Matteo Antonio Sacco  1 , Saverio Gualtieri  1 , Luca Calanna  1 , Pietrantonio Ricci  1 , Isabella Aquila  1
Affiliations
Review

Exploring the Potential of Proteome Analysis as a Promising Tool for Evaluation of Sudden Cardiac Death (SCD) in Forensic Settings: A Literature Review

Matteo Antonio Sacco et al. Int J Mol Sci. .

Abstract

Sudden cardiac death (SCD) represents a global emergency, with a high number of cases affecting all age groups every year. The prevention of these fatal events requires an accurate knowledge of etiology and pathogenesis, which can vary. Autopsy is an indispensable tool in cases of SCD for diagnostic purposes, as well as for judicial and preventive purposes for family members. Despite the completion of all routine post-mortem investigations, it is often complicated for the forensic pathologist to define the triggering cause of these events. The study of the proteome is proving to be extremely promising in the field of human cardiovascular disease. This paper aims to offer a literature review on the study of the proteome in post-mortem cadaveric biological samples obtained from SCD cases. The aim of this work is to outline the state of the art of the scientific advances that protein analysis can offer in the diagnosis of SCD and the limits that various studies have traced up to now. In conclusion, the work defines the future perspectives of this field in SCD, suggesting strategies to overcome the reported limits and improve the diagnostics of these events.

Keywords: forensic sciences; proteomics; sudden cardiac death.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Causes of SCD (created with BioRender.com).
Figure 2
Figure 2
Search method using the PRISMA flowchart.
Figure 3
Figure 3
Biological samples analyzed in various studies on SCD (created with BioRender.com).
Figure 4
Figure 4
Exogenous substances as potential triggers in SCD (created with BioRender.com).
Figure 5
Figure 5
Alternative non-cardiac causes of troponin blood elevation (created with BioRender.com).
See this image and copyright information in PMC

References

    1. Martinez K.A., Bos J.M., Baggish A.L., Phelan D.M., Tobert K.E., Newman D.B., Scherer E., Petek B.J., Ackerman M.J., Martinez M.W. Return-to-Play for Elite Athletes with Genetic Heart Diseases Predisposing to Sudden Cardiac Death. J. Am. Coll. Cardiol. 2023;82:661–670. doi: 10.1016/j.jacc.2023.05.059. - DOI - PubMed
    1. Paratz E.D., van Heusden A., Zentner D., Morgan N., Smith K., Thompson T., James P., Connell V., Pflaumer A., Semsarian C., et al. Sudden Cardiac Death in People with Schizophrenia: Higher Risk, Poorer Resuscitation Profiles, and Differing Pathologies. JACC Clin. Electrophysiol. 2023;9:1310–1318. doi: 10.1016/j.jacep.2023.01.026. - DOI - PubMed
    1. Luo L., Zhao C., Chen N., Dong Y., Li Z., Bai Y., Wu P., Gao C., Guo X. Characterization of global research trends and prospects on sudden coronary death: A literature visualization analysis. Heliyon. 2023;9:e18586. doi: 10.1016/j.heliyon.2023.e18586. - DOI - PMC - PubMed
    1. Andersson J., Fall T., Delicano R., Wennberg P., Jansson J.-H. GDF-15 is associated with sudden cardiac death due to incident myocardial infarction. Resuscitation. 2020;152:165–169. doi: 10.1016/j.resuscitation.2020.05.001. - DOI - PubMed
    1. Nagata M., Ninomiya T., Doi Y., Hata J., Ikeda F., Mukai N., Tsuruya K., Oda Y., Kitazono T., Kiyohara Y. Temporal trends in sudden unexpected death in a general population: The Hisayama Study. Am. Heart J. 2013;165:932–938.e1. doi: 10.1016/j.ahj.2013.02.028. - DOI - PubMed

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