Epidemiology, Ventilation Management and Outcomes of COPD Patients Receiving Invasive Ventilation for COVID-19-Insights from PRoVENT-COVID

Collaborators, Affiliations

Collaborators

PRoVENT-COVID Investigators:
S Ahuja, J P van Akkeren, A G Algera, K C Algoe, R B van Amstel, P van de Berg, D C Bergmans, D I van den Bersselaar, F A Bertens, A J Bindels, J S Breel, M M Bruna, S de Boer, L S Boers, M Botta, O L Baur, H de Bruin, L A Buiteman–Kruizinga, O Cremer, R M Determann, W Dieperink, J van Dijk, D A Dongelmans, M J de Graaff, M S Galekaldridge, L A Hagens, J J Haringman, S T van der Heide, P L van der Heiden, L L Hoeijmakers, L Hol, M W Hollmann, J Horn, E van der Horst, E L Le, D Ivanov, N P Juffermans, E Kho, E S de Klerk, A W Koopman, M Koopmans, I Kucukcelebi, M A Kuiper, D W de Lange, I Martin-Loeches, G Mazzinari, D M van Meenen, N van Mourik, S G Nijbroek, E A Oostdijk, F Paulus, M E Sleeswijk, P E Spronk, A C Strang, W Stilma, P Swart, A M Tsonas, C M A Valk, A P Vlaar, L I Veldhuis, W H van der Ven, P van Velzen, P van Vilet, P van der Voort, L van Welie, B van Wijk, T Winters, W Y Wong, A R van Zanten

Affiliations

¹ Division of Respiratory Disease and Tuberculosis, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10400, Thailand.
² Division of Clinical Epidemiology, Department of Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10400, Thailand.
³ Department of Intensive Care, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The Netherlands.
⁴ Department of Anesthesiology, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The Netherlands.
⁵ Center of Expertise Urban Vitality, Faculty of Health, Amsterdam University of Applied Sciences, 1101 CD Amsterdam, The Netherlands.
⁶ Intensive Care Unit, University College London Hospital, London NW1 2BU, UK.
⁷ Mahidol-Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Bangkok 10400, Thailand.
⁸ Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.
⁹ Department of Anesthesia, General Intensive Care and Pain Management, Division of Cardiothoracic and Vascular Anesthesia & Critical Care Medicine, Medical University of Vienna, 1090 Vienna, Austria.

PMID: 37762725
PMCID: PMC10532133
DOI: 10.3390/jcm12185783

Epidemiology, Ventilation Management and Outcomes of COPD Patients Receiving Invasive Ventilation for COVID-19-Insights from PRoVENT-COVID

Athiwat Tripipitsiriwat et al. J Clin Med. 2023.

. 2023 Sep 5;12(18):5783.

doi: 10.3390/jcm12185783.

Authors

Collaborators

PRoVENT-COVID Investigators:
S Ahuja, J P van Akkeren, A G Algera, K C Algoe, R B van Amstel, P van de Berg, D C Bergmans, D I van den Bersselaar, F A Bertens, A J Bindels, J S Breel, M M Bruna, S de Boer, L S Boers, M Botta, O L Baur, H de Bruin, L A Buiteman–Kruizinga, O Cremer, R M Determann, W Dieperink, J van Dijk, D A Dongelmans, M J de Graaff, M S Galekaldridge, L A Hagens, J J Haringman, S T van der Heide, P L van der Heiden, L L Hoeijmakers, L Hol, M W Hollmann, J Horn, E van der Horst, E L Le, D Ivanov, N P Juffermans, E Kho, E S de Klerk, A W Koopman, M Koopmans, I Kucukcelebi, M A Kuiper, D W de Lange, I Martin-Loeches, G Mazzinari, D M van Meenen, N van Mourik, S G Nijbroek, E A Oostdijk, F Paulus, M E Sleeswijk, P E Spronk, A C Strang, W Stilma, P Swart, A M Tsonas, C M A Valk, A P Vlaar, L I Veldhuis, W H van der Ven, P van Velzen, P van Vilet, P van der Voort, L van Welie, B van Wijk, T Winters, W Y Wong, A R van Zanten

Affiliations

¹ Division of Respiratory Disease and Tuberculosis, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10400, Thailand.
² Division of Clinical Epidemiology, Department of Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10400, Thailand.
³ Department of Intensive Care, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The Netherlands.
⁴ Department of Anesthesiology, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The Netherlands.
⁵ Center of Expertise Urban Vitality, Faculty of Health, Amsterdam University of Applied Sciences, 1101 CD Amsterdam, The Netherlands.
⁶ Intensive Care Unit, University College London Hospital, London NW1 2BU, UK.
⁷ Mahidol-Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Bangkok 10400, Thailand.
⁸ Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.
⁹ Department of Anesthesia, General Intensive Care and Pain Management, Division of Cardiothoracic and Vascular Anesthesia & Critical Care Medicine, Medical University of Vienna, 1090 Vienna, Austria.

PMID: 37762725
PMCID: PMC10532133
DOI: 10.3390/jcm12185783

Abstract

Chronic obstructive pulmonary disease (COPD) is a risk factor for death in patients admitted to intensive care units (ICUs) for respiratory support. Previous reports suggested higher mortality in COPD patients with COVID-19. It is yet unknown whether patients with COPD were treated differently compared to non-COPD patients. We compared the ventilation management and outcomes of invasive ventilation for COVID-19 in COPD patients versus non-COPD patients. This was a post hoc analysis of a nation-wide, observational study in the Netherlands. COPD patients were compared to non-COPD patients with respect to key ventilation parameters. The secondary endpoints included adjunctive treatments for refractory hypoxemia, and 28-day mortality. Of a total of 1090 patients, 88 (8.1%) were classified as having COPD. The ventilation parameters were not different between COPD patients and non-COPD patients, except for FiO₂, which was higher in COPD patients. Prone positioning was applied more often in COPD patients. COPD patients had higher 28-day mortality than non-COPD patients. COPD had an independent association with 28-day mortality. In this cohort of patients who received invasive ventilation for COVID-19, only FiO₂ settings and the use of prone positioning were different between COPD patients and non-COPD patients. COPD patients had higher mortality than non-COPD patients.

Keywords: ARDS; COPD; COVID-19; invasive ventilation; outcome; ventilation management.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses or interpretation of the data; in the writing of the manuscript; or in the decision to publish the results.

Figures

**Figure 1**
Cumulative distribution of ventilatory characteristics. The worst available value for each parameter was used.

**Figure 2**
Kaplan–Meier graph showing mortality in COPD patients and non-COPD patients.

See this image and copyright information in PMC

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Epidemiology, Ventilation Management and Outcomes of COPD Patients Receiving Invasive Ventilation for COVID-19-Insights from PRoVENT-COVID

Collaborators

Affiliations

Epidemiology, Ventilation Management and Outcomes of COPD Patients Receiving Invasive Ventilation for COVID-19-Insights from PRoVENT-COVID

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Figures

References

LinkOut - more resources

Full Text Sources