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. 2023 Sep 7;12(18):5811.
doi: 10.3390/jcm12185811.

Sex-Comparative Outcomes of the T-Branch Device for the Treatment of Complex Aortic Aneurysms

Petroula Nana  1 , Katarzyna Jama  2 , Tilo Kölbel  1 , Konstantinos Spanos  1   3 , Giuseppe Panuccio  1 , Tomasz Jakimowicz  2 , Fiona Rohlffs  1
Affiliations

Sex-Comparative Outcomes of the T-Branch Device for the Treatment of Complex Aortic Aneurysms

Petroula Nana et al. J Clin Med. .

Abstract

Introduction: Females are at increased risk of mortality compared to males after complex endovascular aortic repair. This study aims to examine sex-related peri-operative and follow-up outcomes in patients managed with the t-Branch device.

Methods: A two-center retrospective analysis of patients managed with the off-the-shelf t-Branch device (Cook Medical Inc., Bjaeverskov, Denmark) between 1 January 2014 and 30 September 2020 was performed. Primary outcomes were sex-comparative 30-day mortality, major adverse events (MAEs) and spinal cord ischemia (SCI).

Results: A total of 542 patients were included; 28.0% were females. Urgent repair and type I-III thoracoabdominal aneurysms were more common among females (52.6% vs. 34%, p = 0.01, and 57.1% vs. 35.8%, p = 0.004). Technical success was similar (97.4% vs. 96.9%, p = 0.755), as well as early mortality (16.2% in females vs. 10.8% in males; p = 0.084). SCI rates were similar between groups (13.6% vs. 9.2% p = 0.183). MAEs were more common in females; 33.7% vs. 21.4% (p = 0.022). Multivariate analysis did not identify sex as an independent predictor of adverse events. The 12-month survival rate was 75.7% (SE 0.045) for females and 84.1% (SE 0.026) for males (log rank, p = 0.10).

Conclusions: Sex was not detected as an independent factor of mortality, MAEs and SCI within patients managed with the t-Branch device. Feasibility was high in both groups. No significant difference was shown in survival during the 12-month follow-up.

Keywords: branched repair; females; major adverse events; mortality; sex; spinal cord ischemia.

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Conflict of interest statement

Tilo Kölbel is a consultant and proctor for and has intellectual property with Cook Medical, and receives royalties, speaking fees, and research, travel, and educational grants. Tomacz Jakimowicz is a consultant and proctor for HammerMed, the Polish distributor of Cook Medical, and receives royalties, speaking fees, and travel grants. All authors have completed the ICMJE uniform disclosure form and declare no support from any organization for the submitted work; no financial relationships with any organizations that might have an interest in the submitted work; and no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1
Kaplan–Meier scheme presenting follow-up mortality in females and males after complex endovascular repair using the t-Branch device. A non-significant difference was detected (log rank, p = 0.10). Footnotes: SE: standard error.
See this image and copyright information in PMC

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