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Review
. 2023 Sep 14;12(18):5972.
doi: 10.3390/jcm12185972.

A Relation between Obstructive Sleep Apnea in Pregnancy and Delivering Small for Gestational Age Infant-A Systematic Review

Alicja Grajczyk  1 , Karolina Dżaman  1 , Katarzyna Czerwaty  1 , Monika Kasperczak  2 , Magdalena Zgliczyńska  2 , Anna Stępień  1 , Katarzyna Kosińska-Kaczyńska  2
Affiliations
Review

A Relation between Obstructive Sleep Apnea in Pregnancy and Delivering Small for Gestational Age Infant-A Systematic Review

Alicja Grajczyk et al. J Clin Med. .

Abstract

Obstructive sleep apnea (OSA) during pregnancy can negatively affect both the mother and the baby. Our main goal is to show whether there is an association between OSA during pregnancy and delivering small for gestational age (SGA) infants. This systematic review was conducted according to the PRISMA 2020 statement using three databases: MEDLINE via PubMed, Scopus, and Cochrane Library. All databases were last accessed on 1 June 2023. The implemented systematic literature search identified 744 articles. After excluding reviews, meta-analyses, book chapters, case reports, and letters, 47 studies were analyzed, 18 of which finally met the inclusion criteria. The included studies mainly indicate that OSA during pregnancy may not significantly impact SGA, but some of them have shown the existence of this relation. Nevertheless, it is recommended that all pregnant women should be screened for symptoms of OSA and that sleep tests should be performed on those who show signs of it. Detecting and treating OSA early in pregnancy can help reduce the condition's negative effects. However, more extensive studies are still needed to gather clear evidence on the impact of an OSA diagnosis on mothers and babies.

Keywords: birth weight; obstructive sleep apnea; pregnancy; sleep hypopnea; small for gestational age; upper airway resistance.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Maternal and infant complications of OSA in pregnancy.
Figure 2
Figure 2
PRISMA 2020 flow diagram for new systematic reviews included searches of databases and registered only [37].
See this image and copyright information in PMC

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