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Review
. 2023 Sep 20;12(18):6070.
doi: 10.3390/jcm12186070.

Relationship between Prostate Inflammation and Periodontal Disease-A Systematic Review and Meta-Analysis

Pablo Ortíz de Urbina Comerón  1 , Álvaro Zubizarreta-Macho  1   2 , Ana Belén Lobo Galindo  2 , José María Montiel-Company  3 , María-Fernanda Lorenzo-Gómez  1   4 , Javier Flores Fraile  1
Affiliations
Review

Relationship between Prostate Inflammation and Periodontal Disease-A Systematic Review and Meta-Analysis

Pablo Ortíz de Urbina Comerón et al. J Clin Med. .

Abstract

The aim of this systematic review and meta-analysis was to analyze the association between periodontal disease and prostate inflammation with a null hypothesis stating that periodontal disease does not increase the incidence of prostate inflammation.

Materials and methods: A systematic literature review and meta-analysis of longitudinal observational cohort and case-control studies that evaluated the odds ratio or hazard ratio and confidence interval was undertaken based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations (2020). A total of four databases were consulted in the literature search: PubMed-Medline, Scopus, Embase, and Web of Science. After eliminating duplicated articles and applying the inclusion criteria, seven articles were selected for the qualitative and quantitative analyses.

Results: Four observational cohort studies and three observational cohort case-control studies were included in the meta-analysis. The four observational cohort studies were combined using the random effects model to estimate a hazard ratio of 1.32 with a confidence interval of 95% between 0.87 and 1.77. The meta-analysis presented high heterogeneity (Q test = 56.1; p value < 0.001; I2 = 94.9%). Moreover, the three observational case-control studies were combined using the random effects model to estimate an odds ratio of 1.62 with a confidence interval of 95% between 1.41 and 1.84. The meta-analysis presented high heterogeneity (Q test = 1.07; p value = 0.782; I2 = 0%).

Conclusions: The incidence of periodontal disease does not increase the risk of the incidence of prostate inflammation.

Keywords: hazard ratio; odds ratio; periodontitis; prostate specific-antigen; prostatitis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram.
Figure 2
Figure 2
Forest plot of the hazard ratio meta-analysis of prostatitis in periodontal patients versus non-periodontal patients [21,22,23,24].
Figure 3
Figure 3
Forest plot of the odds ratio meta-analysis of prostatitis in periodontal patients versus non-periodontal patients [25,26,27].
Figure 4
Figure 4
Initial hazard ratio funnel plot and after trim-and-fill adjustment.
Figure 5
Figure 5
Initial odds ratio funnel plot and after trim-and-fill adjustment.
See this image and copyright information in PMC

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