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Review
. 2023 Sep 20;12(18):6081.
doi: 10.3390/jcm12186081.

Limb Salvage and Survival in Chronic Limb-Threatening Ischemia: The Need for a Fast-Track Team-Based Approach

Giorgio Ventoruzzo  1 , Giulia Mazzitelli  1 , Umberto Ruzzi  1 , Francesco Liistro  2 , Alessia Scatena  3 , Eugenio Martelli  4   5   6
Affiliations
Review

Limb Salvage and Survival in Chronic Limb-Threatening Ischemia: The Need for a Fast-Track Team-Based Approach

Giorgio Ventoruzzo et al. J Clin Med. .

Abstract

Chronic limb-threatening ischemia (CLTI) represents the end-stage form of peripheral arterial disease (PAD) and is associated with a very poor prognosis and high risk of limb loss and mortality. It can be considered very similar to a terminal cancer disease, reflecting a large impact on quality of life and healthcare costs. The aim of this study is to offer an overview of the relationship between CLTI, limb salvage, and mortality, with a focus on the need of a fast-track team-based management that is a driver to achieve better survival results. This review can be useful to improve management of this growing impact disease, and to promote the standardisation of care and communication between specialist and non-specialist healthcare professionals.

Keywords: chronic limb-threatening ischemia; critical limb ischemia; limb salvage; mortality; peripheral arterial disease; survival.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Algorithm of the Arezzo fast-track team-based management of CLTI patients with tissue loss. ABI, ankle-brachial index; TcPO2, transcutaneous oxygen pressure; WIfi, wound, ischemia, foot infection classification; CLTI, chronic limb-threatening ischemia; DUS, duplex ultrasound; AGF, angiography; CTA, computerized tomography angiography; CFA, common femoral artery; PTA, percutaneous transluminal angioplasty; BP, bypass; EVR, endovascular revascularisation; PBMNC, peripheral blood mononuclear cells.
See this image and copyright information in PMC

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