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Editorial
. 2023 Aug 27;13(9):1313.
doi: 10.3390/jpm13091313.

Novel Biomarkers to Guide Immunotherapy De-Escalation in the Neoadjuvant Setting in Triple-Negative Breast Cancer

Affiliations
Editorial

Novel Biomarkers to Guide Immunotherapy De-Escalation in the Neoadjuvant Setting in Triple-Negative Breast Cancer

Shipra Gandhi. J Pers Med. .

Abstract

Triple-negative breast cancer (TNBC) has the highest incidence of disease recurrence and distant metastases among breast cancer subtypes, leading to significant rates of morbidity and mortality [...].

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Rugo H.S., Olopade O.I., DeMichele A., Yau C., van’t Veer L.J., Buxton M.B., Hogarth M., Hylton N.M., Paoloni M., Perlmutter J., et al. Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer. N. Engl. J. Med. 2016;375:23–34. doi: 10.1056/NEJMoa1513749. - DOI - PMC - PubMed
    1. Santonja A., Sanchez-Munoz A., Lluch A., Chica-Parrado M.R., Albanell J., Chacon J.I., Antolin S., Jerez J.M., de la Haba J., de Luque V., et al. Triple negative breast cancer subtypes and pathologic complete response rate to neoadjuvant chemotherapy. Oncotarget. 2018;9:26406–26416. doi: 10.18632/oncotarget.25413. - DOI - PMC - PubMed
    1. Cortazar P., Zhang L., Untch M., Mehta K., Costantino J.P., Wolmark N., Bonnefoi H., Cameron D., Gianni L., Valagussa P., et al. Pathological complete response and long-term clinical benefit in breast cancer: The CTNeoBC pooled analysis. Lancet. 2014;384:164–172. doi: 10.1016/S0140-6736(13)62422-8. - DOI - PubMed
    1. Schmid P., Cortes J., Dent R., Pusztai L., McArthur H., Kummel S., Bergh J., Denkert C., Park Y.H., Hui R., et al. Event-free Survival with Pembrolizumab in Early Triple-Negative Breast Cancer. N. Engl. J. Med. 2022;386:556–567. doi: 10.1056/NEJMoa2112651. - DOI - PubMed
    1. Schmid P., Cortes J., Dent R., Pusztai L., McArthur H., Kümmel S., Bergh J., Denkert C., Park Y.H., Hui R., et al. VP7-2021: KEYNOTE-522: Phase III study of neoadjuvant pembrolizumab + chemotherapy vs. placebo + chemotherapy, followed by adjuvant pembrolizumab vs. placebo for early-stage TNBC. Ann. Oncol. 2021;32:1198–1200. doi: 10.1016/j.annonc.2021.06.014. - DOI

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