Circuits and Biomarkers of the Central Nervous System Relating to Astronaut Performance: Summary Report for a NASA-Sponsored Technical Interchange Meeting

Affiliations

¹ NASA Ames Research Center, Moffett Field, CA 94035, USA.
² KBR, Houston, TX 77058, USA.
³ Universities Space Research Association (USRA), Moffett Field, CA 94035, USA.
⁴ Department of Physical Therapy & Rehabilitation Science, University of California, San Francisco, CA 94110, USA.
⁵ Department of Neurological Surgery, University of California, San Francisco, CA 94110, USA.
⁶ Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21205, USA.
⁷ Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD 20814, USA.
⁸ Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁹ Department of Basic Sciences, Division of Biomedical Engineering Sciences (BMES), Loma Linda University Health, Loma Linda, CA 92354, USA.
¹⁰ Integrative Neurochemistry Laboratory, Behavioral Biology Program, McLean Hospital-Harvard Medical School, Belmont, MA 02478, USA.
¹¹ NASA Johnson Space Center, Houston, TX 77058, USA.

PMID: 37763256
PMCID: PMC10532466
DOI: 10.3390/life13091852

Circuits and Biomarkers of the Central Nervous System Relating to Astronaut Performance: Summary Report for a NASA-Sponsored Technical Interchange Meeting

Joshua S Alwood et al. Life (Basel). 2023.

. 2023 Aug 31;13(9):1852.

doi: 10.3390/life13091852.

Authors

Affiliations

¹ NASA Ames Research Center, Moffett Field, CA 94035, USA.
² KBR, Houston, TX 77058, USA.
³ Universities Space Research Association (USRA), Moffett Field, CA 94035, USA.
⁴ Department of Physical Therapy & Rehabilitation Science, University of California, San Francisco, CA 94110, USA.
⁵ Department of Neurological Surgery, University of California, San Francisco, CA 94110, USA.
⁶ Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21205, USA.
⁷ Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD 20814, USA.
⁸ Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁹ Department of Basic Sciences, Division of Biomedical Engineering Sciences (BMES), Loma Linda University Health, Loma Linda, CA 92354, USA.
¹⁰ Integrative Neurochemistry Laboratory, Behavioral Biology Program, McLean Hospital-Harvard Medical School, Belmont, MA 02478, USA.
¹¹ NASA Johnson Space Center, Houston, TX 77058, USA.

PMID: 37763256
PMCID: PMC10532466
DOI: 10.3390/life13091852

Abstract

Biomarkers, ranging from molecules to behavior, can be used to identify thresholds beyond which performance of mission tasks may be compromised and could potentially trigger the activation of countermeasures. Identification of homologous brain regions and/or neural circuits related to operational performance may allow for translational studies between species. Three discussion groups were directed to use operationally relevant performance tasks as a driver when identifying biomarkers and brain regions or circuits for selected constructs. Here we summarize small-group discussions in tables of circuits and biomarkers categorized by (a) sensorimotor, (b) behavioral medicine and (c) integrated approaches (e.g., physiological responses). In total, hundreds of biomarkers have been identified and are summarized herein by the respective group leads. We hope the meeting proceedings become a rich resource for NASA's Human Research Program (HRP) and the community of researchers.

Keywords: CNS; astronaut; behavior; biomarker; brain circuit; cognition; performance.

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Conflict of interest statement

The authors declare no conflict of interest.

References

1. Kiffer F., Alexander T., Anderson J.E., Groves T., Wang J., Sridharan V., Boerma M., Allen A.R. Late Effects of 16O-Particle Radiation on Female Social and Cognitive Behavior and Hippocampal Physiology. Radiat. Res. 2019;191:278–294. doi: 10.1667/RR15092.1. - DOI - PMC - PubMed
1. NASA. CBS . Integrated Research Plan to Assess the Combined Effects of Space Radiation, Altered Gravity, and Isolation and Confinement on Crew Health and Performance: Problem Statement. NASA; Washington, DC, USA: 2019.
1. Tu D., Basner M., Smith M.G., Williams E.S., Ryder V.E., Romoser A.A., Ecker A., Aeschbach D., Stahn A.C., Jones C.W., et al. Dynamic ensemble prediction of cognitive performance in spaceflight. Sci. Rep. 2022;12:11032. doi: 10.1038/s41598-022-14456-8. - DOI - PMC - PubMed
1. Grandjean P. Paracelsus Revisited: The Dose Concept in a Complex World. Basic. Clin. Pharmacol. Toxicol. 2016;119:126–132. doi: 10.1111/bcpt.12622. - DOI - PMC - PubMed
1. Carnell L.S. Spaceflight medical countermeasures: A strategic approach for mitigating effects from solar particle events. Int. J. Radiat. Biol. 2021;97:S125–S131. doi: 10.1080/09553002.2020.1820603. - DOI - PubMed

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Circuits and Biomarkers of the Central Nervous System Relating to Astronaut Performance: Summary Report for a NASA-Sponsored Technical Interchange Meeting

Affiliations

Circuits and Biomarkers of the Central Nervous System Relating to Astronaut Performance: Summary Report for a NASA-Sponsored Technical Interchange Meeting

Authors

Affiliations

Abstract

Conflict of interest statement

References

Grants and funding

LinkOut - more resources

Full Text Sources