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. 2023 Sep 5;15(18):3863.
doi: 10.3390/nu15183863.

The Impact of Prenatal Vitamin D on Enamel Defects and Tooth Erosion: A Systematic Review

Gianina Tapalaga  1 , Bogdan Andrei Bumbu  2 , Sandhya Rani Reddy  3 , Sai Diksha Vutukuru  4 , Akhila Nalla  4 , Felix Bratosin  5   6 , Roxana Manuela Fericean  5   6 , Catalin Dumitru  7 , Doru Ciprian Crisan  7 , Nicoleta Nicolae  7 , Magda Mihaela Luca  8
Affiliations

The Impact of Prenatal Vitamin D on Enamel Defects and Tooth Erosion: A Systematic Review

Gianina Tapalaga et al. Nutrients. .

Abstract

Prenatal Vitamin D has been suggested to be critical for dental health in children, affecting outcomes including the prevalence of enamel defects and tooth erosion. This systematic review aimed to evaluate the potential impact of prenatal Vitamin D levels on these dental health outcomes. A total of seven studies, involving 6978 participants, were included after a comprehensive search of PubMed, Web of Science, and Scopus from 2013 to June 2023. The average age of mothers varied across studies, with Vitamin D levels or supplementation practices displaying significant variation among the study populations. The age of children at examination ranged from 3.6 to 6.6 years. The analysis demonstrated a diverse association between Vitamin D levels and dental outcomes, with enamel defects reported in 21.1% to 64% of the children and opacities ranging from 36% to 79.5% across studies. Maternal Vitamin D insufficiency was identified as a significant risk factor for enamel defects in one study (OR: 3.55), whereas high prenatal Vitamin D levels indicated a protective effect against Hypomineralized Second Primary Molars (OR: 0.84) and Molar Incisor Hypomineralization (OR: 0.95) in another. Conversely, low Vitamin D levels increased the risk of enamel hypoplasia (OR: 1.29) and dental decay. The maternal and child demographics varied greatly across the studies, and the assessment and prevalence of Vitamin D deficiency or insufficiency were heterogenous. This review illuminates the potential influence of prenatal Vitamin D on dental health in children, underscoring the importance of adequate Vitamin D levels during pregnancy. However, more robust research is required to establish the optimal Vitamin D intake during pregnancy to ensure healthy dental outcomes in children.

Keywords: Vitamin D; dental enamel erosion; dentistry; pregnancy; tooth discoloration; tooth diseases.

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Conflict of interest statement

The authors declare no conflict of interest.

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Figure 1
PRISMA Flow Diagram.
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Funnel plot for publication bias.
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