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. 2023 Sep 19;15(18):4056.
doi: 10.3390/nu15184056.

A Multi-Omics and Human Biomonitoring Approach to Assessing the Effectiveness of Fortified Balanced Energy-Protein Supplementation on Maternal and Newborn Health in Burkina Faso: A Study Protocol

Yuri Bastos-Moreira  1   2 , Lionel Ouédraogo  2   3 , Marthe De Boevre  1 , Alemayehu Argaw  2 , Brenda de Kok  2 , Giles T Hanley-Cook  2 , Lishi Deng  2 , Moctar Ouédraogo  4 , Anderson Compaoré  4 , Kokeb Tesfamariam  2 , Rasmané Ganaba  4 , Lieven Huybregts  2   5 , Laeticia Celine Toe  2   6 , Carl Lachat  2 , Patrick Kolsteren  2 , Sarah De Saeger  1   7 , Trenton Dailey-Chwalibóg  2
Affiliations

A Multi-Omics and Human Biomonitoring Approach to Assessing the Effectiveness of Fortified Balanced Energy-Protein Supplementation on Maternal and Newborn Health in Burkina Faso: A Study Protocol

Yuri Bastos-Moreira et al. Nutrients. .

Abstract

Fortified balanced energy-protein (BEP) supplementation is a promising intervention for improving maternal health, birth outcomes and infant growth in low- and middle-income countries. This nested biospecimen sub-study aimed to evaluate the physiological effect of multi-micronutrient-fortified BEP supplementation on pregnant and lactating women and their infants. Pregnant women (15-40 years) received either fortified BEP and iron-folic acid (IFA) (intervention) or IFA only (control) throughout pregnancy. The same women were concurrently randomized to receive either a fortified BEP supplement during the first 6 months postpartum in combination with IFA for the first 6 weeks (i.e., intervention) or the postnatal standard of care, which comprised IFA alone for 6 weeks postpartum (i.e., control). Biological specimens were collected at different timepoints. Multi-omics profiles will be characterized to assess the mediating effect of BEP supplementation on the different trial arms and its effect on maternal health, as well as birth and infant growth outcomes. The mediating effect of the exposome in the relationship between BEP supplementation and maternal health, birth outcomes and infant growth were characterized via biomonitoring markers of air pollution, mycotoxins and environmental contaminants. The results will provide holistic insight into the granular physiological effects of prenatal and postnatal BEP supplementation.

Keywords: MISAME-III; balanced energy–protein supplementation; exposome; metabolomics; metagenomics; proteomics.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
MISAME-III efficacy trial timeline: intervention and control arms. BEP, micronutrient-fortified balanced energy–protein; IFA, iron–folic acid.
Figure 2
Figure 2
Data produced in the biospecimen sub-study (BioSpé) of MISAME-III. These data will be leveraged to assess the physiological effects of micronutrient-fortified balanced energy–protein (BEP) supplementation on maternal health, infant birth and infant growth outcomes through an analysis of multi-omics profiles, the human biomonitoring of contaminants and measurements of relative telomere length (TL) and mitochondrial DNA content (mtDNAc).
See this image and copyright information in PMC

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