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Review
. 2023 Sep 20;12(9):1180.
doi: 10.3390/pathogens12091180.

Influence of Vitamin D on Periodontal Inflammation: A Review

Mohamed M Meghil  1 , Christopher W Cutler  1
Affiliations
Review

Influence of Vitamin D on Periodontal Inflammation: A Review

Mohamed M Meghil et al. Pathogens. .

Abstract

The active form of vitamin D is the hormonally active 1,25(OH)2D3 (Vit D) vitamin, which plays an important role in bone biology and host immunity. The vitamin D receptor (VDR) is a nuclear ligand-dependent transcription factor expressed by many cells. Ligation of VDR by VitD regulates a wide plethora of genes and physiologic functions through the formation of the complex Vit D-VDR signaling cascade. The influence of Vit D-VDR signaling in host immune response to microbial infection has been of interest to many researchers. This is particularly important in oral health and diseases, as oral mucosa is exposed to a complex microbiota, with certain species capable of causing disruption to immune homeostasis. In this review, we focus on the immune modulatory roles of Vit D in the bone degenerative oral disease, periodontitis.

Keywords: gingivitis; immunology; periodontitis; vitamin D.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of the primary mechanisms through which vitamin D regulates the innate immune response.
Figure 2
Figure 2
Schematic representation of the mechanisms through which vitamin D regulates the crosstalk between dendritic cells (DCs) and T-cell.
Figure 3
Figure 3
Immune modulatory role of vitamin D.
See this image and copyright information in PMC

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