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Review
. 2023 Aug 22;15(9):1783.
doi: 10.3390/v15091783.

Arboviral Risk Associated with Solid Organ and Hematopoietic Stem Cell Grafts: The Prophylactic Answers Proposed by the French High Council of Public Health in a National Context

Bruno Pozzetto  1   2   3 , Gilda Grard  4   5 , Guillaume Durand  4   5 , Marie-Claire Paty  6 , Pierre Gallian  7   8 , Sophie Lucas-Samuel  9 , Stéphanie Diéterlé  9 , Muriel Fromage  10 , Marc Durand  1 , Didier Lepelletier  1 , Christian Chidiac  1   11 , Bruno Hoen  1   12 , Xavier Nicolas de Lamballerie  4   5   8
Affiliations
Review

Arboviral Risk Associated with Solid Organ and Hematopoietic Stem Cell Grafts: The Prophylactic Answers Proposed by the French High Council of Public Health in a National Context

Bruno Pozzetto et al. Viruses. .

Abstract

Diseases caused by arboviruses are on the increase worldwide. In addition to arthropod bites, most arboviruses can be transmitted via accessory routes. Products of human origin (labile blood products, solid organs, hematopoietic stem cells, tissues) present a risk of contamination for the recipient if the donation is made when the donor is viremic. Mainland France and its overseas territories are exposed to a complex array of imported and endemic arboviruses, which differ according to their respective location. This narrative review describes the risks of acquiring certain arboviral diseases from human products, mainly solid organs and hematopoietic stem cells, in the French context. The main risks considered in this study are infections by West Nile virus, dengue virus, and tick-borne encephalitis virus. The ancillary risks represented by Usutu virus infection, chikungunya, and Zika are also addressed more briefly. For each disease, the guidelines issued by the French High Council of Public Health, which is responsible for mitigating the risks associated with products of human origin and for supporting public health policy decisions, are briefly outlined. This review highlights the need for a "One Health" approach and to standardize recommendations at the international level in areas with the same viral epidemiology.

Keywords: France; Usutu virus; West Nile virus; Zika virus; chikungunya virus; dengue virus; hematopoietic stem cell; products of human origin; solid organ; tick-borne encephalitis virus.

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Conflict of interest statement

The authors declare that they have no competing interests regarding the subject of this review.

Figures

Figure 1
Figure 1
Location of French overseas territories and administrative regions. Overseas departments are shown in blue. Overseas collectivities and territories are shown in magenta (French Austral and Antarctic Territories not shown). The embedded map shows the 18 French administrative regions.
Figure 2
Figure 2
Number of annual cases of West Nile virus infection identified in humans, horses, and birds in mainland France, 2001–2022 (source: Santé publique France).
Figure 3
Figure 3
Endemic and epidemic circulation of dengue virus on Martinique (blue line) and Guadeloupe (red line) islands, 2003–2021. The more prevalent serotype(s) is (are) shown for each outbreak. Source: Santé publique France.
Figure 4
Figure 4
Worldwide distribution of tick-borne encephalitis virus (TBEV). Source: Centers for Disease Control and Prevention, 7 March 2022 (available at https://www.cdc.gov/tick-borne-encephalitis/geographic-distribution/index.html).
See this image and copyright information in PMC

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