Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Sep 20;15(9):1958.
doi: 10.3390/v15091958.

The Association between CCL5/RANTES SNPs and Susceptibility to HIV-1 Infection: A Meta-Analysis

Marcos Jessé Abrahão Silva  1 , Rebecca Lobato Marinho  2 , Pabllo Antonny Silva Dos Santos  3 , Carolynne Silva Dos Santos  3 , Layana Rufino Ribeiro  2 , Yan Corrêa Rodrigues  1   2   4 , Karla Valéria Batista Lima  2 , Luana Nepomuceno Gondim Costa Lima  2
Affiliations
Review

The Association between CCL5/RANTES SNPs and Susceptibility to HIV-1 Infection: A Meta-Analysis

Marcos Jessé Abrahão Silva et al. Viruses. .

Abstract

Genetic polymorphisms in genes that encode natural ligands of CCR5 (the main human HIV coreceptor), such as CCL5/RANTES, can alter the levels of secretion of these peptides. This article sought to review the relationship between single nucleotide polymorphisms (SNPs) of CCL5/RANTES and HIV-1 disease susceptibility. A meta-analysis was conducted through 17 articles found from January 1999 to December 2022 in the PUBMED, Science Direct, Medline, and SciELO databases. A total of three SNPs were identified and investigated under their dominant genotypic model and through a fixed-effects model. In terms of the SNP rs2107538 (G > A), in Africa and Asia, it has a protective role (OR = 0.56; 95% CI = 0.41-0.76; p = 0.0002, and OR = 0.88; 95% CI = 0.76-1.02; p = 0.08, respectively). In terms of the SNP rs2280788 (C > G), in Europe and America, it shows a higher risk role (OR = 1.92; 95% CI = 1.06-3.47; p = 0.03, and OR = 0.94; 95% CI = 0.94-1.11; p = 0.04, respectively), but in the population of Asia, with its mutant allele, it has a protective role (OR = 0.76; 95% CI = 0.63-0.93; p = 0.007). In terms of the SNP rs2280789 (T > C), no significant associations were found. Both SNPs rs2107538 and rs2280788 have a positive transcriptional effect on the RANTES/CCL5 gene, while SNP rs2280789 causes a decrease in gene expression levels. This study suggests that there is an association between the increased expression of CCL5/RANTES and a lower risk of AIDS. Therefore, further studies are needed to arrive at a definitive conclusion, and these results may help establish scientific bases for effective HIV/AIDS control strategies.

Keywords: CCL5; HIV; disease association studies; genetic polymorphisms.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart representing the stages of selection, eligibility, and inclusion of studies for analysis. Belém, PA, Brazil (2023).
Figure 2
Figure 2
Forest plot of the associations between each SNP of the CCL5/RANTES gene and HIV-1 susceptibility in a dominant genotypic model. Forest plot for the SNP rs2107538, GG vs. GA + AA (A). Forest plot for the SNP rs2280788, CC vs. CG + GG (B). Forest plot for the SNP rs2280789, TT vs. TC + CC (C) [11,14,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37].
Figure 3
Figure 3
Funnel plot of each SNP of the CCL5/RANTES gene in this meta-analysis. Funnel plot for the analysis of the SNP rs2107538 (A). Funnel plot for the analysis of the SNP rs2280788 (B). Forest plot for the analysis of the SNP rs2280789 (C) [11,14,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37].
Figure 4
Figure 4
Location of the related SNPs and their association with the structure of the CCL5/RANTES gene and its protein. Location of the CCL5/RANTES gene in the human chromosome (A). Investigated SNPs and their effects on this gene expression (B). Effects of the SNPs in the protein levels (C).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Pereira G.F.M., Pimenta M.C., Giozza S.P., Caruso A.R., Bastos F.I., Guimarães M.D.C. HIV/AIDS, STIs and Viral Hepatitis in Brazil: Epidemiological Trends. Rev. Bras. Epidemiol. 2019;22:e190001. doi: 10.1590/1980-549720190001.supl.1. - DOI - PubMed
    1. He H., Ou Z., Yu D., Li Y., Liang Y., He W., Gao Y., Wu F., Chen Q. Spatial and Temporal Trends in HIV/AIDS Burden Among Worldwide Regions From 1990 to 2019: A Secondary Analysis of the Global Burden of Disease Study 2019. Front. Med. 2022;9:808318. doi: 10.3389/fmed.2022.808318. - DOI - PMC - PubMed
    1. World Health Organization. UNAIDS HIV Data and Statistics. [(accessed on 18 September 2023)]. Available online: https://www.who.int/teams/global-hiv-hepatitis-and-stis-programmes/hiv/s....
    1. Siliciano J.D., Siliciano R.F. Recent Developments in the Effort to Cure HIV Infection: Going beyond N = 1. J. Clin. Investig. 2016;126:409–414. doi: 10.1172/JCI86047. - DOI - PMC - PubMed
    1. Al-Jabri A.A. Mechanisms of Host Resistance against HIV Infection and Progression to AIDS. Sultan Qaboos Univ. Med. J. 2007;7:82. - PMC - PubMed