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. 2023 Oct;90(4):e13775.
doi: 10.1111/aji.13775.

Role of tumor necrosis factor-alpha -238 G>A promoter region polymorphism on recurrent miscarriage: An association study and meta-analysis

Neha Sudhir  1 , Mandeep Kaur  1 , Sukhjashanpreet Singh  1 , Archana Beri  2 , Tajinder Kaur  3 , Badaruddoza  1 , Anupam Kaur  1
Affiliations

Role of tumor necrosis factor-alpha -238 G>A promoter region polymorphism on recurrent miscarriage: An association study and meta-analysis

Neha Sudhir et al. Am J Reprod Immunol. 2023 Oct.

Abstract

Background: Recurrent miscarriage (RM) is defined as the loss of two or more consecutive pregnancies. A functional SNP, -238G>A in the promoter region of TNF-α, affects the gene transcription activity with implications on human pregnancy. Previous limited studies, linking the TNF-α -238 G>A to the risk of recurrent miscarriage have been inconclusive.

Material and method: The PCR-RLFP technique was used to evaluate this polymorphism in 199 RM cases and 215 control women from Amritsar, Punjab. For a meta-analysis, a total of 13 eligible studies (including the present study) comprising 2947 cases and 2933 controls were included. To evaluate the association among different genetic models, odds ratio with a 95% confidence interval (CI) and chi-square were used.

Results: Genotype and allelic frequency did not differ significantly between both groups (p = .07 and p = .24, respectively). In the present meta-analysis, a significant association was found with the recessive model (OR-1.78 CI:1.24-2.55, p = .002).

Conclusion: Although, TNF-α -238 G>A polymorphism did not provide any risk in the case-control study but provided risk towards the development of RM with the recessive genetic model in the pooled analysis.

Keywords: meta-analysis; polymorphism; recurrent miscarriage; tumor necrosis factor-alpha.

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References

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