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. 2023 Sep 28;38(3):167-171.
doi: 10.4274/MMJ.galenos.2023.84042.

Results of Routine Antenatal Screening for Cytomegalovirus at a Tertiary Center

Duygu Tugrul Ersak  1 , Izzet Ozgurluk  1 , Ayse Gulcin Bastemur  1 , Esra Gulen Yildiz  1 , Selcan Sinaci  1 , Ezgi Turgut  1 , Ozgur Kara  1 , Atakan Tanacan  1 , Dilek Sahin  1
Affiliations

Results of Routine Antenatal Screening for Cytomegalovirus at a Tertiary Center

Duygu Tugrul Ersak et al. Medeni Med J. .

Abstract
in English, Turkish

Objective: Cytomegalovirus (CMV) is the most common viral infection. In this study, we discussed the results of pregnant women who underwent antenatal CMV screening in a tertiary center and the value of CMV antenatal screening.

Methods: For this retrospective study, the data of pregnant patients with antenatal CMV screening test results between 2019 and 2022 were obtained from hospital records. CMV immunoglobulin M (IgM), CMV IgG, anti-IgG avidity test results, amniocentesis, CMV polymerase chain reaction (PCR), and the outcome of the babies were recorded.

Results: A total of 31,912 CMV IgM and 26,969 CMV IgG tests were performed. CMV IgG seropositivity was observed in 78.99% of pregnant women, and 0.09% of the pregnant women were confirmed to have a positive CMV IgM test result. Pregnant women with positive IgM accompanying low avidity were referred to perinatology clinics for detailed ultrasonography and amniocentesis. Only 3 of the 44 pregnant women who underwent amniocentesis were confirmed to have positive CMV PCR testing.

Conclusions: CMV screening should be preserved for pregnant women with ultrasonographic findings at high risk of congenital CMV infection.

Amaç: Sitomegalovirüs (CMV), en sık viral enfeksiyondur. Bu çalışmada tersiyer bir merkezde antenatal CMV taraması yaptıran gebelerin sonuçlarını ve antenatal CMV taramasının değerini tartışmayı amaçladık.

Yöntemler: Bu retrospektif çalışma için 2019-2022 yılları arasında antenatal dönemde CMV tarama testi sonuçları olan gebelerin verileri hastane kayıtlarından elde edildi. CMV immünoglobulin M (IgM), CMV IgG, anti-IgG avidite, amniyosentez, CMV polimeraz zincirleme reaksiyonu (PZR) test sonuçları ve bebeklerin yenidoğan dönemindeki sonuçları kaydedildi.

Bulgular: Toplam 31.912 CMV IgM ve 26.969 CMV IgG testi yapılmıştı. Gebelerin %78,99’unda CMV IgG seropozitifliği görülmüş ve %0,09’unun CMV IgM test sonucunun pozitif olduğu doğrulanmıştır. Düşük aviditeye eşlik eden IgM pozitifliği olan gebeler ayrıntılı ultrasonografi ve amniyosentez için perinatoloji kliniğine yönlendirildi. Amniyosentez yapılan 44 gebeden sadece 3’ünün CMV PZR testinin pozitif olduğu doğrulandı.

Sonuçlar: Konjenital CMV enfeksiyonu açısından yüksek riskli ultrasonografik bulguları olan gebelerde CMV taraması uygulanmalıdır.

Keywords: Cytomegalovirus; antenatal screening; fetal infection; pregnancy; prevalence.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
CMV screening flowchart. CMV: Cytomegalovirus, IgG: Immunoglobulin G, IgM: Immunoglobulin M, PCR: Polymerase chain reaction
See this image and copyright information in PMC

References

    1. Mussi-Pinhata MM, Yamamoto AY, Moura Brito RM, et al. Birth prevalence and natural history of congenital cytomegalovirus infection in a highly seroimmune population. Clin Infect Dis. 2009;49:522–8. - PMC - PubMed
    1. Zuhair M, Smit GSA, Wallis G, et al. Estimation of the worldwide seroprevalence of cytomegalovirus: A systematic review and meta-analysis. Rev Med Virol. 2019;29:2034. - PubMed
    1. Sert Y, Ozgu-Erdinc AS, Saygan S, Engin Ustun Y. Antenatal Cytomegalovirus Infection Screening Results of 32,188 Patients in a Tertiary Referral Center: A Retrospective Cohort Study. Fetal Pediatr Pathol. 2019;38:112–20. - PubMed
    1. Simonazzi G, Curti A, Cervi F, et al. Perinatal outcomes of non-primary maternal cytomegalovirus infection: a 15-year experience. Fetal Diagn Ther. 2018;43:138–42. - PubMed
    1. Chatzakis C, Ville Y, Makrydimas G, Dinas K, Zavlanos A, Sotiriadis A. Timing of primary maternal cytomegalovirus infection and rates of vertical transmission and fetal consequences. Am J Obstet Gynecol. 2020;223:870–83. - PubMed

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