Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep 13;8(3):157-165.
doi: 10.14744/bej.2023.85688. eCollection 2023.

Could Corneal Densitometry be a Progression Criterion for Subclinical Keratoconus?

Hasan Kiziltoprak  1 , Kemal Tekin  2 , Halil Ibrahim Atesoglu  3 , Dilara Ozkoyuncu Kocabas  4 , Mustafa Koc  5 , Mustafa Ilker Toker  2
Affiliations

Could Corneal Densitometry be a Progression Criterion for Subclinical Keratoconus?

Hasan Kiziltoprak et al. Beyoglu Eye J. .

Abstract

Objectives: The objective of this study is to investigate the changes in topometry, tomography, and corneal densitometry in subclinical keratoconus (SK) at the 6-month interval.

Methods: The clinical keratoconus and SK groups included 25 eyes; the control group included 22 eyes from 22 patients. Corneal topographic, tomographic, topometric, and densitometric values obtained using the Pentacam HR imaging system were analyzed.

Results: Posterior elevation (PE), Keratoconus index (KI), index of height asymmetry (IHA), index of height decentration (IHD), Dp, Da, Final D, maximum pachymetric progression index (PPImax), and maximum Ambrósio relational thickness parameters showed significant changes between the baseline and the 6th-month follow-up in SK group (p<0.05 for all values). There were significant changes in all zones except a central layer of 6-10 zone, anterior, and central layer of 10-12 zone between the baseline and the 6th-month follow-up in the SK group (p<0.05, for all values). The changes in mean±standard deviation of KI, IHA, IHD, PPImax parameters, and corneal densitometry values of the posterior layer of 0-2 mm and 2-6 mm zones were significant in the SK group compared to the controls (p<0.05, for all values).

Conclusion: PE, KI, IHA, IHD, and PPImax parameters as well as increasing corneal light backscatter of the posterior central layer might be useful for follow-up of progression of SK. New multimeric parameters created by combinations of topometric, tomographic, and corneal densitometry parameters could be the future of SK follow-up.

Keywords: Densitometry; pentacam; subclinical keratoconus; tomography; topometry.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Similar articles

See all similar articles

References

    1. Jeyabalan N, Shetty R, Ghosh A, Anandula VR, Ghosh AS, Kumaramanickavel G. Genetic and genomic perspective to understand the molecular pathogenesis of keratoconus. Indian J Ophthalmol. 2013;61:384–8. - PMC - PubMed
    1. Gomes JA, Tan D, Rapuano CJ, Belin MW, Ambrósio R, Jr, Guell JL, et al. Global consensus on keratoconus and ectatic diseases. Cornea. 2015;34:359–69. - PubMed
    1. Koc M, Tekin K, Tekin MI, Uzel MM, Kosekahya P, Ozulken K, et al. An early finding of keratoconus:Increase in corneal densitometry. Cornea. 2018;37:580–6. - PubMed
    1. Koc M, Tekin K, Kiziltoprak H, Inanc M, Kosekahya P, Ozulken K, et al. Topometric and tomographic evaluation of subclinical keratoconus. Ophthalmic Epidemiol. 2020;27:289–97. - PubMed
    1. Ozkan HH, Koc M, Kiziltoprak H, Tekin K, Aydemir E. Evaluation of topographic, tomographic, topometric, densitometric, and aberrometric features of cornea with pentacam HR system in subclinical keratoconus. Int Ophthalmol. 2021;41:1729–41. - PubMed

LinkOut - more resources