Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar-Apr;16(2):114-117.
doi: 10.4103/apc.apc_18_23. Epub 2023 Aug 16.

Clinical profile and outcome of cardiac manifestations in patients presenting with multisystem inflammatory syndrome in children associated with SARS-CoV-2 infection

Gautam Singal  1 , Akash Batta  1 , Siddharth Bhargava  2 , Sushil Kumar  2 , Rohit Tandon  1 , Anshuman Gupta  1 , Abhishek Goyal  1 , Shibba Takkar Chhabra  1 , Naved Aslam  1 , Gurpreet Singh Wander  1 , Bishav Mohan  1
Affiliations

Clinical profile and outcome of cardiac manifestations in patients presenting with multisystem inflammatory syndrome in children associated with SARS-CoV-2 infection

Gautam Singal et al. Ann Pediatr Cardiol. 2023 Mar-Apr.

Abstract

Multisystem inflammatory syndrome in children (MIS-C) can cause significant morbidity and mortality in children. This study was conducted to assess the pattern and outcome of cardiac abnormalities in MIS-C. This retrospective study was conducted in children with MIS-C between 1 month and 18 years. We enrolled 53 children with a mean age of 7.78 ± 4.62 years. Overall, 35.8% of children with MIS-C had cardiac manifestations in the form of coronary artery abnormalities (CAAs) or left ventricular (LV) dysfunction. Younger age (P 0.009) and high C-reactive protein at admission (P = 0.001) were significant predictors of cardiac involvement. CAAs were seen in 11.3% of children. On follow-up, 67% and 83% of children showed regression of CAA at 1 and 6 months, respectively. 24.5% of patients had presented with LV dysfunction. LV ejection fraction improved significantly at 1 month (P = 0.002) and 6 months (P = 0.001). Cardiac outcomes in MIS-C were favorable with timely identification and treatment.

Keywords: Cardiac outcome; coronary artery abnormalities; left ventricular dysfunction; multisystem inflammatory syndrome in children.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Coronary artery involvement
Figure 2
Figure 2
Coronary aneurysm of LMCA and LAD. LMCA: Left main coronary artery, LAD: Left anterior descending
Figure 3
Figure 3
Comparison of pretreatment LVEF with LVEF at 1- and 6-month follow-up. LVEF: Left ventricular ejection fraction
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Centers for Disease Control and Prevention Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19) May 2020. [[Last accessed on 18 Dec 2022]]. Available online: https://emergency.cdc.gov/han/2020/han00432.asp .
    1. Sperotto F, Friedman KG, Son MB, VanderPluym CJ, Newburger JW, Dionne A. Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: A comprehensive review and proposed clinical approach. Eur J Pediatr. 2021;180:307–22. - PMC - PubMed
    1. Multisystem inflammatory syndrome in children and adolescents with COVID-19. Scientific brief: World Health Organization 15 May 2020. [[Last accessed on 18 Dec 2022]]. Available from: https://www.who.int/publications/i/item/multisystem-inflammatory-syndrom... .
    1. McCrindle BW, Rowley AH, Newburger JW, Burns JC, Bolger AF, Gewitz M, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: A scientific statement for health professionals from the American Heart Association. Circulation. 2017;135:e927–99. - PubMed
    1. Henderson LA, Canna SW, Friedman KG, Gorelik M, Lapidus SK, Bassiri H, et al. American college of rheumatology clinical guidance for multisystem inflammatory syndrome in children associated with SARS-CoV-2 and hyperinflammation in pediatric COVID-19: Version 1. Arthritis Rheumatol. 2020;72:1791–805. - PMC - PubMed