Clozapine for Management of Neuropsychiatric Symptoms in Dementia with Lewy Bodies: Case Report and Literature Review

Nikoo Hashemi¹, Dean Yang², David Shergold³, Gayla Tennen⁴, Chris Fan-Lun⁵

Affiliations

¹ , BSc, MSc, PharmD, was, at the time this manuscript was prepared a PharmD candidate with the Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario. She has now graduated.
² , BScPhm, BCGP, is a staff pharmacist with the Department of Pharmacy, Sunnybrook Health Sciences Centre, Toronto, Ontario.
³ , MD, is a staff physician with the Department of Family and Community Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario.
⁴ , MD, FRCPC, is a Lecturer with the Department of Psychiatry, University of Toronto, and a staff psychiatrist with the Department of Clinical Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario.
⁵ , BScPhm, ACPR, BCGP, is an Adjunct Lecturer with the Leslie Dan Faculty of Pharmacy, University of Toronto, and is a Clinical Coordinator with the Department of Pharmacy, Sunnybrook Health Sciences Centre, Toronto, Ontario.

PMID: 37767388
PMCID: PMC10522355
DOI: 10.4212/cjhp.3390

Case Reports

Clozapine for Management of Neuropsychiatric Symptoms in Dementia with Lewy Bodies: Case Report and Literature Review

Nikoo Hashemi et al. Can J Hosp Pharm. 2023.

. 2023 Sep 1;76(4):340-345.

doi: 10.4212/cjhp.3390. eCollection 2023 Fall.

Authors

Nikoo Hashemi¹, Dean Yang², David Shergold³, Gayla Tennen⁴, Chris Fan-Lun⁵

Affiliations

¹ , BSc, MSc, PharmD, was, at the time this manuscript was prepared a PharmD candidate with the Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario. She has now graduated.
² , BScPhm, BCGP, is a staff pharmacist with the Department of Pharmacy, Sunnybrook Health Sciences Centre, Toronto, Ontario.
³ , MD, is a staff physician with the Department of Family and Community Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario.
⁴ , MD, FRCPC, is a Lecturer with the Department of Psychiatry, University of Toronto, and a staff psychiatrist with the Department of Clinical Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario.
⁵ , BScPhm, ACPR, BCGP, is an Adjunct Lecturer with the Leslie Dan Faculty of Pharmacy, University of Toronto, and is a Clinical Coordinator with the Department of Pharmacy, Sunnybrook Health Sciences Centre, Toronto, Ontario.

PMID: 37767388
PMCID: PMC10522355
DOI: 10.4212/cjhp.3390

No abstract available

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Conflict of interest statement

Competing interests: Chris Fan-Lun received a patient care grant from the Ontario Branch of the Canadian Society of Hospital Pharmacists (paid to the institution) and has received speaker’s fees from the Regional Geriatric Program of Toronto. No other competing interests were declared.

Figures

**FIGURE 1**
Timeline of changes in the patient’s psychoactive medications.

See this image and copyright information in PMC

References

1. Public Health Agency of Canada; Neurological Health Charities Canada. Report HP35-45/2014E-PDF. Minister of Health (Canada); 2014. Mapping connections: an understanding of neurological conditions in Canada. [cited 2023 Jan 18]. Available from: https://www.canada.ca/content/dam/phac-aspc/migration/phac-aspc/publicat....
1. Mckeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, et al. Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium. Neurology. 2017;89(1):88–100. doi: 10.1212/WNL.0000000000004058. - DOI - PMC - PubMed
1. Walker Z, Possin KL, Boeve BF, Aarsland D. Lewy body dementias. Lancet. 2015;386(10004):1683–97. doi: 10.1016/S0140-6736(15)00462-6. - DOI - PMC - PubMed
1. Kyle K, Bronstein JM. Treatment of psychosis in Parkinson’s disease and dementia with Lewy bodies: a review. Parkinsonism Relat Disord. 2020;75:55–62. doi: 10.1016/j.parkreldis.2020.05.026. - DOI - PubMed
1. Vann Jones SA, O’Brien JT. The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies. Psychol Med. 2014;44(4):673–83. doi: 10.1017/S0033291713000494. - DOI - PubMed

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Clozapine for Management of Neuropsychiatric Symptoms in Dementia with Lewy Bodies: Case Report and Literature Review

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Clozapine for Management of Neuropsychiatric Symptoms in Dementia with Lewy Bodies: Case Report and Literature Review

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Conflict of interest statement

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