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. 2023 Aug;175(4):508-512.
doi: 10.1007/s10517-023-05896-x. Epub 2023 Sep 28.

Automated Assessment of the Area of Infiltration by CD8+ Cells in Gastric Carcinoma and Areas of Normal Mucosa as a Significant Prognostic Factor

N V Danilova  1 , I A Mikhailov  2 , V M Khomyakov  3 , A V Chaika  3 , T V Polushkina  4 , T N Sotnikova  4 , N A Oleinikova  2 , P G Mal'kov  2
Affiliations

Automated Assessment of the Area of Infiltration by CD8+ Cells in Gastric Carcinoma and Areas of Normal Mucosa as a Significant Prognostic Factor

N V Danilova et al. Bull Exp Biol Med. 2023 Aug.

Abstract

In 139 patients with verified gastric cancer, the infiltration of the postoperative material with CD8+ cells was analyzed. Automated morphometric analysis of immunostained slides was performed separately in different specimen sites (tumor center, invasive edge, and peritumoral mucosa). The mean area of infiltrating CD8+ cells in the tumor center and in the invasive edge was not predictive, while in the peritumoral mucosa it provided a new negative predictive factor (hazard ratio 2.10; confidence interval 0.87-4.92, Cox regression) reliably associated with the TNM stage (hazard ratio 1.91; confidence interval 0.91-4.61, Cox regression).

Keywords: T lymphocytes; gastric cancer; immune microenvironment; morphometry; prognostic markers.

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