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Comment
. 2023 Oct 17;330(15):1484-1485.
doi: 10.1001/jama.2023.16182.

The Use of Historical Controls in Clinical Trials

Joe D Marion  1 , Andrew D Althouse  2   3
Affiliations
Comment

The Use of Historical Controls in Clinical Trials

Joe D Marion et al. JAMA. .
No abstract available

Plain language summary

This JAMA Guide to Statistics and Methods explains the use of historical controls—persons who had received a specific control treatment in a previous study—when randomizing participants to that control treatment in a subsequent trial may not be practical or ethical.

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