Understanding Infection Risk with Anti-BCMA Bispecific Antibodies
- PMID: 37769160
- PMCID: PMC10618722
- DOI: 10.1158/2643-3230.BCD-23-0157
Understanding Infection Risk with Anti-BCMA Bispecific Antibodies
Abstract
Lancman and colleagues find that infection risk in patients treated with anti-BCMA bispecific antibodies for relapsed/refractory multiple myeloma is associated with severe immunoglobulin deficiency and may be mitigated by immunoglobulin replacement therapy. The study has implications for managing infection risk and raises questions about the optimal duration of treatment with these potent, novel immunotherapies. See related article by Lancman et al., p. 440 (4) .
©2023 American Association for Cancer Research.
Comment on
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IVIg Use Associated with Ten-Fold Reduction of Serious Infections in Multiple Myeloma Patients Treated with Anti-BCMA Bispecific Antibodies.Blood Cancer Discov. 2023 Nov 1;4(6):440-451. doi: 10.1158/2643-3230.BCD-23-0049. Blood Cancer Discov. 2023. PMID: 37769148 Free PMC article.
References
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- Raje NS, Anaissie E, Kumar SK, Lonial S, Martin T, Gertz MA, et al. . Consensus guidelines and recommendations for infection prevention in multiple myeloma: a report from the International Myeloma Working Group. Lancet Haematol 2022;9:e143–61. - PubMed
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