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Comment
. 2023 Sep 28;62(3):2301329.
doi: 10.1183/13993003.01329-2023. Print 2023 Sep.

Reply: Transitioning endothelial cells contribute to pulmonary fibrosis

Xiuju Wu  1 , Kristina I Boström  1   2 , Yucheng Yao  3
Affiliations
Comment

Reply: Transitioning endothelial cells contribute to pulmonary fibrosis

Xiuju Wu et al. Eur Respir J. .

Abstract

Differentiation trajectory from ECs to EC-like myofibroblasts and myofibroblasts may pass through a mesenchymal stage. This trajectory exists in a quiescent state in healthy lungs and may be activated when pathological stimuli trigger pulmonary fibrosis. https://bit.ly/3QWfgyS

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Conflict of interest statement

Conflict of interest: The authors have no potential conflicts of interest to disclose.

Figures

FIGURE 1
FIGURE 1
Endothelial cell (EC)-like myofibroblasts express mesenchymal markers in healthy pulmonary tissues and mesenchymal markers are elevated in human pulmonary fibrosis. a) Violin plots of vimentin expression in cell subclusters from CD34+CD45− pulmonary cells of wild-type mice. b) Violin plots of gene expression of mesenchymal lineage markers in cell subclusters from CD34+CD45− pulmonary cells of healthy human lungs and human pulmonary fibrosis.
See this image and copyright information in PMC

Comment on

References

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