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. 2023 Aug;175(4):459-462.
doi: 10.1007/s10517-023-05886-z. Epub 2023 Sep 28.

Pharmacological Effects of a New Indolinone Derivative in Experimental Pneumonitis in Rats

V V Bykov  1   2 , V S Motov  3 , A V Bykova  3 , V A Khazanov  3 , A I Vengerovskii  4 , V V Udut  5
Affiliations

Pharmacological Effects of a New Indolinone Derivative in Experimental Pneumonitis in Rats

V V Bykov et al. Bull Exp Biol Med. 2023 Aug.

Abstract

We studied the effect of a new indolinone derivative GRS on animal survival and on functioning and histological structure of the lungs in rats with experimental pneumonitis. The rats of experimental groups were intratracheally administered 0.5% aqueous solution of carrageenan under intramuscular anesthesia. Compound GRS (10 mg/kg; a suspension in 0.5% aqueous solution of carboxymethyl cellulose) was orally administered for 4 days starting from the day of carrageenan administration; another rat group received the aqueous solution of carboxymethyl cellulose alone. Control rats received intratracheally isotonic solution of sodium chloride. Animal mortality was registered over 5 days; on day 5, the respiratory parameters were measured, the lungs were weighed, pulmonary edema was evaluated, and histological structure of the lungs was studied. GRS compound improved survival of animals with modeled pneumonitis, restored the respiratory parameters to the level of control animals, and reduced pulmonary edema by 35% and the severity of histological damage score in the lungs by 17% (p<0.05).

Keywords: animal survival; functional and histological disorders; indolinone derivative; pneumonitis model; rats.

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