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. 2023 Sep 28;23(1):209.
doi: 10.1186/s12902-023-01465-5.

Association between a high triglyceride-glucose index and chronic kidney disease in adult patients with latent autoimmune diabetes

Xiuli Fu #  1 , Zihui Xu #  1 , Qin Tan  1 , Wei Wei  1 , Zhongjing Wang  2
Affiliations

Association between a high triglyceride-glucose index and chronic kidney disease in adult patients with latent autoimmune diabetes

Xiuli Fu et al. BMC Endocr Disord. .

Abstract

Background: Insulin resistance (IR) is one of the risk factors for chronic kidney disease (CKD) and diabetes. The triglyceride-glucose (TyG) index is considered a reliable alternative marker of IR. We investigated the correlation between the TyG index and the severity of CKD in patients with latent autoimmune diabetes in adults (LADA).

Methods: This cross-sectional study included 288 patients with LADA in the department of endocrinology at our hospital between January 2018 and January 2022. The TyG index was calculated as Ln [TG (mg/dl) × fasting blood glucose (FBG) (mg/dl) / 2]. All individuals were divided into either a LADA + CKD group or a LADA + non-CKD group according to the presence or absence of CKD. A correlation analysis, logistic regression analysis and receiver operating characteristics curve analysis were performed.

Results: A total of 130 (45.1%) participants were identified as having CKD. Compared with the non-CKD group, the CKD group had a longer disease duration and a higher proportion of smokers; patients were more likely to have hypertension and higher serum creatinine, triglyceride, cholesterol, low-density lipoprotein cholesterol, FBG, uric acid estimated glomerular filtration rates (eGFR) and TyG levels as well as lower high-density lipoprotein cholesterol levels (all P < 0.05). The positive relationship between the TyG index and the urinary albumin/creatinine ratio was significant (r = 0.249, P = 0.010). There was also a significant correlation between the TyG index and the eGFR (r = - 0.211, P = 0.034) after adjusting for confounding factors. The area-under-the-curve value of the TyG index was 0.708 (95% confidence interval: 0.61-0.81, P < 0.001).

Conclusions: The TyG index is significantly associated with the severity of CKD in patients with LADA. This conclusion supports the clinical application of the TyG index for the assessment of kidney disease in patients with LADA.

Keywords: Chronic kidney disease; Insulin resistance; Latent autoimmune diabetes in adults; Triglyceride–glucose index.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The relationship of UACR and TyG in LADA patients
Fig. 2
Fig. 2
ROC analyses of TyG index
See this image and copyright information in PMC

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References

    1. World Health Organization. Classification of diabetes mellitus. Geneva, World Health Organization.; 2019.
    1. Zhou Z, Xiang Y, Ji L, et al. Frequency, immunogenetics, and clinical characteristics of latent autoimmune diabetes in China (LADA China study): a nationwide, multicenter, clinic-based cross-sectional study. Diabetes. 2013;62(2):543–50. doi: 10.2337/db12-0207. - DOI - PMC - PubMed
    1. Guerrero-Romero F, Simental-Mendía LE, González-Ortiz M, et al. The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp. J Clin Endocrinol Metab. 2010;95(7):3347–51. doi: 10.1210/jc.2010-0288. - DOI - PubMed
    1. Hong S, Han K, Park CY. The triglyceride glucose index is a simple and low-cost marker associated with atherosclerotic cardiovascular disease: a population-based study. BMC Med. 2020;18(1):361. doi: 10.1186/s12916-020-01824-2. - DOI - PMC - PubMed
    1. Li M, Zhan A, Huang X, et al. Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type hypertension Registry Study. Cardiovasc Diabetol. 2020;19(1):139. doi: 10.1186/s12933-020-01124-2. - DOI - PMC - PubMed