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Review
. 2023 Sep 12:11:1265153.
doi: 10.3389/fbioe.2023.1265153. eCollection 2023.

Advances of nanotechnology for intracerebral hemorrhage therapy

Jiayan Wang #  1   2 , Tianyou Wang #  3 , Mei Fang #  1   2 , Zexu Wang  2 , Wei Xu  1   2 , Bang Teng  1   2 , Qijuan Yuan  4 , Xin Hu  1
Affiliations
Review

Advances of nanotechnology for intracerebral hemorrhage therapy

Jiayan Wang et al. Front Bioeng Biotechnol. .

Abstract

Intracerebral hemorrhage (ICH), the most devastating subtype of stoke, is of high mortality at 5 years and even those survivors usually would suffer permanent disabilities. Fortunately, various preclinical active drugs have been approached in ICH, meanwhile, the therapeutic effects of these pharmaceutical ingredients could be fully boosted with the assistance of nanotechnology. In this review, besides the pathology of ICH, some ICH therapeutically available active drugs and their employed nanotechnologies, material functions, and therapeutic principles were comprehensively discussed hoping to provide novel and efficient strategies for ICH therapy in the future.

Keywords: bioavailability; functionality; intracerebral hemorrhage; nanotechnologies; safety; therapeutic agents.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer CH declared a shared parent affiliation with the authors to the handling editor at the time of review.

Figures

FIGURE 1
FIGURE 1
Advances of nanotechnology for ICH therapy. Created with Biorender.com.
FIGURE 2
FIGURE 2
Schematic illustration of the secondary brain injury after ICH. Created with Biorender.com.
FIGURE 3
FIGURE 3
Application of nanotechnology in (A) safety and (B) bioavailability for therapeutic agents in ICH. Created with Biorender.com.
FIGURE 4
FIGURE 4
Functions of nanotechnology assisted therapeutic agents for ICH. PBCA: polybutylcyanoacrylate; NP: nanoparticle; cmv: cytomegalovirus; NT-3: neurotrophin-3; HRE: containing hormone response element; tFNA: tetrahedral framework nucleic acid; siCCR2: C-C chemokine receptor 2; PEG: polyethylene glycol; CeNPs: cerium oxide nanoparticles; DFO: deferoxamine; ROS: reactive oxygen species; Menp: polydopamine; PLT: platelet; REP: the repetitive integrin-binding ArgGlyAsp peptide -containing elastin-like polypeptide; Res: resveratrol. Created with Biorender.com.
FIGURE 5
FIGURE 5
Clinical, preclinical, and future therapies for ICH (A) Clinical therapies are surgery and medical management. (B) Preclinical therapies are improved by nanotechnologies including drug loading, post-synthetic modification, etc. (C) Future therapies need to explore more pathological mechanisms underlying ICH, fabricate more multifunctional materials, and develop more advanced technology such as nanotechnology. Created with Biorender.com.
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References

    1. Al-Kassas R., Bansal M., Shaw J. (2017). Nanosizing techniques for improving bioavailability of drugs. J. Control. Release 260, 202–212. 10.1016/j.jconrel.2017.06.003 - DOI - PubMed
    1. Alexander A., Agrawal M., Uddin A., Siddique S., Shehata A. M., Shaker M. A., et al. (2019). <p>Recent expansions of novel strategies towards the drug targeting into the brain</p>. Int. J. Nanomed. 14, 5895–5909. 10.2147/IJN.S210876 - DOI - PMC - PubMed
    1. Bao Q., Hu P., Xu Y., Cheng T., Wei C., Pan L., et al. (2018). Simultaneous blood-brain barrier crossing and protection for stroke treatment based on edaravone-loaded ceria nanoparticles. ACS Nano 12 (7), 6794–6805. 10.1021/acsnano.8b01994 - DOI - PubMed
    1. Bautista W., Adelson P. D., Bicher N., Themistocleous M., Tsivgoulis G., Chang J. J. (2021). Secondary mechanisms of injury and viable pathophysiological targets in intracerebral hemorrhage. Ther. Adv. Neurol. Disord. 14, 175628642110492. 10.1177/17562864211049208 - DOI - PMC - PubMed
    1. Bejot Y., Blanc C., Delpont B., Thouant P., Chazalon C., Daumas A., et al. (2018). Increasing early ambulation disability in spontaneous intracerebral hemorrhage survivors. Neurology 90 (23), e2017–e2024. 10.1212/WNL.0000000000005633 - DOI - PubMed

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