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Review
. 2023 Sep 13:10:1242608.
doi: 10.3389/fcvm.2023.1242608. eCollection 2023.

Comparison of middle-term valve durability between transcatheter aortic valve implantation and surgical aortic valve replacement: an updated systematic review and meta-analysis of RCTs

Tsahi T Lerman  1   2   3 , Amos Levi  2   3 , Troels Højsgaard Jørgensen  4 , Lars Søndergaard  4 , Yeela Talmor-Barkan  2   3 , Ran Kornowski  2   3
Affiliations
Review

Comparison of middle-term valve durability between transcatheter aortic valve implantation and surgical aortic valve replacement: an updated systematic review and meta-analysis of RCTs

Tsahi T Lerman et al. Front Cardiovasc Med. .

Abstract

Background: This study aims to compare valve durability between transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR).

Methods: We conducted a systematic review and meta-analysis using data from randomized controlled trials (RCTs). The primary outcome was structural valve deterioration (SVD). Secondary outcomes were bioprosthetic valve failure, reintervention, effective orifice area (EOA), mean pressure gradient, and moderate-severe aortic regurgitation (AR, transvalvular and/or paravalvular).

Results: Twenty-five publications from seven RCTs consisting of 7,970 patients were included in the analysis with follow-up ranges of 2-8 years. No significant difference was found between the two groups with regard to SVD [odds ratio (OR) 0.72; 95% CI: 0.25-2.12]. The TAVI group was reported to exhibit a statistically significant higher risk of reintervention (OR 2.03; 95% CI: 1.34-3.05) and a moderate-severe AR (OR 6.54; 95% CI: 3.92-10.91) compared with the SAVR group. A trend toward lower mean pressure gradient in the TAVI group [(mean difference (MD) -1.61; 95% CI: -3.5 to 0.28)] and significant higher EOA (MD 0.20; 95% CI: 0.08-0.31) was noted.

Conclusion: The present data indicate that TAVI provides a comparable risk of SVD with favorable hemodynamic profile compared with SAVR. However, the higher risk of significant AR and reintervention was demonstrated.

Systematic review registration: PROSPERO (CRD42022363060).

Keywords: SAVR; TAVI; bioprosthetic valve failure; durability; structural valve deterioration.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Study selection process for inclusion in the meta-analysis (PRISMA flow diagram).
Figure 2
Figure 2
Forest plots for structural valve deterioration.
Figure 3
Figure 3
Forest plots for bioprosthetic valve failure (A) and reintervention (B).
Figure 4
Figure 4
Forest plots for mean gradients (A), effective orifice area (B), moderate–severe aortic regurgitation (C), and moderate–severe paravalvular leak (D).
Figure 5
Figure 5
Mean pressure gradient and effective orifice area during a 5-year follow-up.
See this image and copyright information in PMC

References

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