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Comment
. 2023 Dec 4;220(12):e20231397.
doi: 10.1084/jem.20231397. Epub 2023 Sep 29.

For whom the B(c)ell tolls: CXCL4 AIDs human autoimmunity

Stuart G Tangye  1   2
Affiliations
Comment

For whom the B(c)ell tolls: CXCL4 AIDs human autoimmunity

Stuart G Tangye. J Exp Med. .

Abstract

In this issue of JEM, Çakan et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230944) explore a CXCL4-mediated mechanism by which TLRs cause autoimmunity in human B cells, breaching bone marrow tolerance.

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Comment on

  • TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance.
    Çakan E, Ah Kioon MD, Garcia-Carmona Y, Glauzy S, Oliver D, Yamakawa N, Vega Loza A, Du Y, Schickel JN, Boeckers JM, Yang C, Baldo A, Ivashkiv LB, Young RM, Staudt LM, Moody KL, Nündel K, Marshak-Rothstein A, van der Made CI, Hoischen A, Hayward A, Rossato M, Radstake TRDJ, Cunningham-Rundles C, Ryu C, Herzog EL, Barrat FJ, Meffre E. Çakan E, et al. J Exp Med. 2023 Dec 4;220(12):e20230944. doi: 10.1084/jem.20230944. Epub 2023 Sep 29. J Exp Med. 2023. PMID: 37773045 Free PMC article.

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