Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Dec;37(12):2493-2496.
doi: 10.1038/s41375-023-02046-0. Epub 2023 Sep 29.

Real-world evaluation of UK high hyperdiploidy profile using a large cohort of patients provided by HARMONY data platform

Affiliations

Real-world evaluation of UK high hyperdiploidy profile using a large cohort of patients provided by HARMONY data platform

Amir Enshaei et al. Leukemia. 2023 Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. The definition and outcome of the UK-HeH profile.
A Flow chart illustrating the rules for assigning cases to the definite good (D-GR), provisional good (P-GR), definite poor (D-PR) and provisional poor (P-PR) risk groups; (B) Relapse free survival for the four risk groups; (C) Relapse free survival of final good and poor risk groups; (D) Forest plot comparing the relapse rate of patients in the poor risk HeH group compared to the patients in the good risk HeH group stratified by sex, age, white cell count, NCI risk, MRD and year of diagnosis.

References

    1. Moorman AV, Ensor HM, Richards SM, Chilton L, Schwab C, Kinsey SE, et al. Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial. Lancet Oncol. 2010;11:429–38. doi: 10.1016/S1470-2045(10)70066-8. - DOI - PubMed
    1. Malard F, Mohty M. Acute lymphoblastic leukaemia. Lancet. 2020;395:1146–62. doi: 10.1016/S0140-6736(19)33018-1. - DOI - PubMed
    1. Paulsson K, Johansson B. High hyperdiploid childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2009;48:637–60. doi: 10.1002/gcc.20671. - DOI - PubMed
    1. Teachey DT, Pui CH. Comparative features and outcomes between paediatric T-cell and B-cell acute lymphoblastic leukaemia. Lancet Oncol. 2019;20:e142–e54. doi: 10.1016/S1470-2045(19)30031-2. - DOI - PMC - PubMed
    1. Heerema NA, Sather HN, Sensel MG, Zhang T, Hutchinson RJ, Nachman JB, et al. Prognostic impact of trisomies of chromosomes 10, 17, and 5 among children with acute lymphoblastic leukemia and high hyperdiploidy (> 50 chromosomes) J Clin Oncol. 2000;18:1876–87. doi: 10.1200/JCO.2000.18.9.1876. - DOI - PubMed

Publication types