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. 2023 Nov 1;42(11):e403-e406.
doi: 10.1097/INF.0000000000004093. Epub 2023 Sep 22.

The Clinical Course of SARS-CoV-2 Infection in Patients With Autoimmune Neutropenia: A Retrospective Case Series Study

Gioacchino Andrea Rotulo  1 , Giulia Ceglie  2   3 , Annalisa Candino  4 , Antonella Merola  4 , Elisa Profeti  4 , Carmela Giancotta  1 , Stefania Mercadante  4 , Veronica Santilli  1 , Nicola Cotugno  1 , Paolo Palma  1   5 , Giuseppe Palumbo  2   5 , Andrea Finocchi  1   5
Affiliations

The Clinical Course of SARS-CoV-2 Infection in Patients With Autoimmune Neutropenia: A Retrospective Case Series Study

Gioacchino Andrea Rotulo et al. Pediatr Infect Dis J. .

Abstract

Severe acute respiratory syndrome coronavirus 2 infection in children with autoimmune neutropenia may be a cause for concern. In this retrospective study, none of the 24 autoimmune neutropenia cases manifested severe coronavirus disease 2019. We found a significant improvement in neutrophils and a reduction in lymphocytes at post-infection follow-up compared with the median of previous values. We speculate that this paradoxical effect may be due to postinfection immunological phenomena.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

References

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    1. Rotulo GA, Palma P. Understanding COVID-19 in children: immune determinants and post-infection conditions. Pediatr Res. 2023;94:434–442.

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