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Comment
. 2023 Dec 1;208(11):1249-1250.
doi: 10.1164/rccm.202309-1622LE.

Reply to Yasuma et al

Allison E Norlander  1   2   3 , Masako Abney  1 , Jacqueline-Yvonne Cephus  1 , Caroline E Roe  4 , Jonathan M Irish  4 , Nicholas J Shelburne  1 , Dawn C Newcomb  1 , Anna R Hemnes  1 , R Stokes Peebles Jr  1   4   5
Affiliations
Comment

Reply to Yasuma et al

Allison E Norlander et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Effect of the prostaglandin I2 analogues epoprostenol or treprostinil on (A) T regulatory cell (Treg) (Foxp3+CD4+) percentage, (B) Foxp3 mean fluorescence intensity in Tregs, (C) CD44 mean fluorescence intensity in Tregs, and (D) ratio of T effector cells (CD4+Foxp3−) to Tregs (CD4+Foxp3+). Analysis was performed with a paired t test. *P < 0.05. MFI = mean fluorescence intensity; PGI2 = prostaglandin I2.
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References

    1. Norlander AE, Abney M, Cephus JY, Roe CE, Irish JM, Shelburne NJ, et al. Prostaglandin I2 therapy promotes regulatory T cell generation in patients with pulmonary arterial hypertension. Am J Respir Crit Care Med . 2023;208:737–739. - PMC - PubMed
    1. Greig SL, Scott LJ, Plosker GL. Epoprostenol (Veletri®, Caripul®): a review of its use in patients with pulmonary arterial hypertension. Am J Cardiovasc Drugs . 2014;14:463–470. - PubMed
    1. Kumar P, Thudium E, Laliberte K, Zaccardelli D, Nelsen A. A comprehensive review of treprostinil pharmacokinetics via four routes of administration. Clin Pharmacokinet . 2016;55:1495–1505. - PMC - PubMed

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