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Comment
. 2023 Oct 9;41(10):1696-1698.
doi: 10.1016/j.ccell.2023.08.005. Epub 2023 Sep 28.

Genetically informed therapy for lymphoma: the discomfiting benefit of lumping splits

Cynthia K Hahn  1 , Adam C Palmer  2 , David M Weinstock  3
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Comment

Genetically informed therapy for lymphoma: the discomfiting benefit of lumping splits

Cynthia K Hahn et al. Cancer Cell. .
Free article

Abstract

Zhang et al. report a randomized phase 2 trial for diffuse large B cell lymphoma (DLBCL) that compared standard of care (R-CHOP) to R-CHOP combined with one of 5 agents matched to an individual lymphoma's genetics. Overall, the matching strategy significantly outperformed R-CHOP, laying the foundation for a paradigm-shifting phase 3 trial.

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Conflict of interest statement

Declaration of interests A.C.P. received consulting fees from Merck, Astra Zeneca, and Kymera and research support from Prelude Therapeutics. D.M.W. is an employee of Merck and Co., owns equity in Merck and Co.; Bantam; Ajax; and Travera; received consulting fees from Astra Zeneca; Secura; Novartis; and Roche/Genentech; and received research support from Daiichi Sankyo; Astra Zeneca; Verastem; Abbvie; Novartis; Abcura; and Surface Oncology.

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