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Comment
. 2023 Nov 13;41(11):1846-1848.
doi: 10.1016/j.ccell.2023.09.002. Epub 2023 Sep 28.

Beyond bacteria: How the intratumor mycobiome modulates lung adenocarcinoma progression

Zahraa Rahal  1 , Humam Kadara  2
Affiliations
Comment

Beyond bacteria: How the intratumor mycobiome modulates lung adenocarcinoma progression

Zahraa Rahal et al. Cancer Cell. .

Abstract

Increasing evidence suggests that tumors harbor diverse microbiomes, adding complexity to the tumor microenvironment. In this issue of Cancer Cell, Liu et al. highlight the role of the intratumor mycobiome, specifically Aspergillus sydowii, in promoting lung adenocarcinoma progression. A. sydowii enhances the recruitment and activation of myeloid-derived suppressor cells via IL-1β signaling driven by the β-glucan-mediated Dectin-1/CARD9 pathway.

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Conflict of interest statement

Declaration of interests H.K. received funding from Johnson and Johnson outside the scope of this work.

Figures

Figure 1.
Figure 1.. Aspergillus sydowii-mediated immune modulation in lung adenocarcinoma progression
Liu et al. describe how the intratumor mycobiome, especially Aspergillus sydowii, influences lung adenocarcinoma progression. A. sydowii triggers the expansion and activation of myeloid-derived suppressor cells through IL-1β signaling initiated by the β-glucan-triggered Dectin-1/CARD9 pathway. This then reduces cytotoxic T lymphocyte activity and results in more T regulatory cells (Tregs) and PD-1+ CD8+ T cells, ultimately leading to tumor progression.
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