Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Sep;23(5):495-502.
doi: 10.7861/clinmed.2023-0049. Epub 2023 Sep 29.

SARS-CoV-2 vaccines and myocarditis

Agata Katarzyna Sularz  1 , Alina Hua  1 , Tevfik Ismail  2
Affiliations
Review

SARS-CoV-2 vaccines and myocarditis

Agata Katarzyna Sularz et al. Clin Med (Lond). 2023 Sep.

Abstract

The development of safe and effective vaccines against severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) was a major turning point in the fight against the Coronavirus 2019 (COVID-19) pandemic. However, pharmacovigilance has revealed a small but significant incidence of cardiac inflammation manifesting clinically as myocarditis or pericarditis, particularly in younger vaccine recipients. The incidence is the highest among men under age 40 within a week of receiving the second dose of the mRNA vaccine. In this review, we summarise the evidence for, and guidelines in relation to, SARS-CoV2 vaccine-related myocarditis.

Keywords: COVID-19; SARS-CoV-2 vaccine-related myocarditis; mRNA vaccine; myocarditis; vaccine safety.

PubMed Disclaimer

References

    1. Medicine and Healthcare Products Regulatory Agency. Coronavirus vaccine - summary of Yellow Card reporting. www.gov.uk/government/publications/coronavirus-covid-19-vaccine-adverse-... [Accessed 1 August 2023].
    1. Twentyman E, Wallace M, Roper LE, et al. . Interim recommendation of the Advisory Committee on Immunization Practices for Use of the Novavax COVID-19 Vaccine in Persons Aged ≥18 years-United States, July 2022. MMWR Morb Mortal Wkly Rep 2022;71:988–92. - PMC - PubMed
    1. Straus W, Urdaneta V, Esposito DB, et al. . Analysis of myocarditis among 252 million mRNA-1273 recipients worldwide. Clin Infect Dis 2023;76:e544–52. - PMC - PubMed
    1. Oster ME, Shay DK, Su JR, et al. . Myocarditis cases reported after mRNA-based COVID-19 vaccination in the US from December 2020 to August 2021. JAMA 2022;327:331–40. - PMC - PubMed
    1. Witberg G, Barda N, Hoss S, et al. . Myocarditis after Covid-19 vaccination in a large health care organization. N Engl J Med 2021;385:2132–9. - PMC - PubMed