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. 2024 Mar;28(1):359-370.
doi: 10.1007/s11325-023-02927-9. Epub 2023 Sep 29.

Sleep-related disorders and lower urinary tract symptoms in middle-aged and elderly males: a cross-sectional study based on NHANES 2005-2008

Junhao Chen #  1   2   3 , Zhenghuan Liu #  1   2 , Luchen Yang  1   2 , Jing Zhou  1   2 , Kai Ma  1   2 , Zhufeng Peng  1 , Qiang Dong  4
Affiliations

Sleep-related disorders and lower urinary tract symptoms in middle-aged and elderly males: a cross-sectional study based on NHANES 2005-2008

Junhao Chen et al. Sleep Breath. 2024 Mar.

Abstract

Purpose: Lower urinary tract symptoms (LUTS) and sleep disorders both commonly affect people's quality of life. This study aimed to explore the associations between sleep-related disorders and LUTS through epidemiological investigations.

Methods: Data were generated from the cross-sectional study called the National Health and Nutrition Examination Survey (NHANES) 2005-2008. Multivariable logistic regression models were conducted to investigate the relationships between sleep-related disorders and LUTS.

Results: A total of 2516 men were included in the study. Participants sleeping ≤ 6 h/night had higher odds ratios of LUTS (OR: 1.38; 95% CI 1.08, 1.77), daytime LUTS (OR: 1.26; 95% CI 1.03, 1.54), and nocturia (OR: 1.23; 95% CI 1.02, 1.49) than those sleeping 7-8 h/night. Participants who required > 30 min to fall asleep had an approximately 39% higher odds ratios of nocturia than those who fell asleep within 6 to 30 min (OR: 1.39; 95% CI 1.12, 1.73). Sleep problems were positively related to LUTS (OR: 1.42; 95% CI 1.11, 1.82), daytime LUTS (OR: 1.32; 95% CI 1.08, 1.61), urinary hesitancy (OR: 1.75; 95% CI 1.31, 2.34), and nocturia (OR: 1.52; 95% CI 1.26, 1.84). Obstructive sleep apnea (OSA) symptoms were positively associated with urinary incontinence (OR: 1.52; 95% CI 1.12, 2.08). In addition, participants with daytime sleepiness were at higher prevalence of LUTS (OR: 1.66; 95% CI 1.29, 2.15), daytime LUTS (OR: 1.44; 95% CI 1.16, 1.78), urinary hesitancy (OR: 1.95; 95% CI 1.45, 2.63), and nocturia (OR: 1.66; 95% CI 1.35, 2.05).

Conclusion: The findings suggested that sleep-related disorders were associated with LUTS, daytime LUTS, urinary hesitancy, incomplete emptying, urinary incontinence, and nocturia in middle-aged and elderly males.

Keywords: Clinical study; Epidemiology; Lower urinary tract symptoms; NHANES; Sleep disorders.

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References

    1. Irwin DE, Kopp ZS, Agatep B, Milsom I, Abrams P (2011) Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction. BJU Int 108(7):1132–1138 - DOI - PubMed
    1. Irwin DE, Milsom I, Kopp Z, Abrams P, Artibani W, Herschorn S (2009) Prevalence, severity, and symptom bother of lower urinary tract symptoms among men in the EPIC study: impact of overactive bladder. Eur Urol 56(1):14–20 - DOI - PubMed
    1. Wei JT, Calhoun E, Jacobsen SJ (2005) Urologic diseases in America project: benign prostatic hyperplasia. J Urol 173(4):1256–1261 - DOI - PubMed
    1. Chughtai B, Thomas D, Kaplan S (2016) α-Blockers, 5-α-reductase inhibitors, acetylcholine, β3 agonists, and phosphodiesterase-5s in medical management of lower urinary tract symptoms/benign prostatic hyperplasia: how much do the different formulations actually matter in the classes? Urol Clinics N Am 43(3):351–356 - DOI
    1. Kakizaki H, Koyanagi T (2000) Current view and status of the treatment of lower urinary tract symptoms and neurogenic lower urinary tract dysfunction. BJU Int 85(Suppl 2):25–30 - DOI - PubMed

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