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. 2023 Dec;70(12):e30696.
doi: 10.1002/pbc.30696. Epub 2023 Sep 30.

Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN)

Wendy Hsiao  1   2 , Yimei Li  3   4 , Kelly Getz  3   4   5 , Lusha Cao  6 , Edward Krause  6 , Mark Ramos  6 , Judy Lee  7 , Maria Monica Gramatges  8   9 , Karen R Rabin  8   9 , Michael E Scheurer  8   9 , Richard Aplenc  3   5 , Michelle Denburg  2   4   5 , Tamara P Miller  7   10
Affiliations

Acute and chronic kidney injury during therapy for pediatric acute leukemia: A report from the Leukemia Electronic Abstraction of Records Network (LEARN)

Wendy Hsiao et al. Pediatr Blood Cancer. 2023 Dec.

Abstract

Children with acute leukemia are at increased risk of kidney injury. Using electronic health record data from three centers between 2010 and 2018, this study retrospectively described acute kidney injury (AKI) and chronic kidney disease (CKD) prevalence in children with acute lymphoblastic or myeloid leukemia (ALL, AML) using Common Terminology Criteria for Adverse Events (CTCAE) and Kidney Disease Improving Global Outcomes (KDIGO) definitions. AKI during therapy was 25% (ALL) and 32% (AML) using CTCAE, versus 84% (ALL) and 74% (AML) using KDIGO. CKD prevalence was low and Grade 1/Stage 2. Further investigation is needed to optimally define kidney injury in acute leukemia.

Keywords: acute kidney disease; acute kidney injury; acute lymphoblastic leukemia; acute myeloid leukemia; chronic kidney disease.

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Conflict of interest statement

CONFLICT OF INTEREST STATEMENT

The authors declare they have no conflicts of interest.

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