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Case Reports
. 2023 Dec;27(6):369-372.
doi: 10.1016/j.jaapos.2023.08.007. Epub 2023 Sep 29.

Multimodal prenatal and postnatal imaging of microphthalmia with cyst

Taylor Kolosky  1 , Olivia Uddin  1 , Bhakti Panchal  1 , He Eun Forbes  1 , Moran R Levin  1 , Alexander Engelmann  1 , Sifa Turan  2 , Ozhan M Turan  2 , Janet L Alexander  3
Affiliations
Case Reports

Multimodal prenatal and postnatal imaging of microphthalmia with cyst

Taylor Kolosky et al. J AAPOS. 2023 Dec.

Abstract

Congenital ocular anomalies may be detected on prenatal imaging using fetal ultrasound and magnetic resonance imaging (MRI), although standard prenatal ultrasound for fetal physical development does not currently include ocular and orbital evaluation. We present the case of a male infant born at 39 weeks' gestation with microphthalmia with cyst that was characterized using serial multimodal imaging, including fetal ultrasound and MRI, B-scan ultrasonography, ultrasound biomicroscopy, and postnatal MRI. Multiple prenatal and postnatal imaging modalities yielded comparable evaluations of the ocular and orbital pathology, validating the prenatal assessments.

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Figures

FIG 1.
FIG 1.
A, 2D axial view of the orbits on fetal ultrasound. B, 3D axial view, silhouette, and x-ray mode from fetal ultrasound. C, 3D tomographic imaging 2 mm slices starting from the forehead (−3) to posterior end of the orbits (4) from fetal ultrasound. D, 2D axial view of the orbital size on fetal ultrasound.
FIG 2.
FIG 2.
A, Axial ultrasound biomicroscopy (UBM) image showing left eye with lens thickness measurement and A-scan overlay. B, Axial UBM image displaying left eye with anterior chamber depth and corneal thickness measurements. C, Axial UBM image of right eye. D, UBM image showing angle of right eye.
FIG 3.
FIG 3.
Axial T2-weighted flair magnetic resonance imaging (MRI), with measurements indicated. A, Sagittal T2 MRI of left orbit with intraocular measurements. B, Axial T2 MRI with intraorbital cyst measurements. C, Axial T2 MRI with lens thickness measurements. D, Axial T2 MRI with measurement of left orbital contents.
See this image and copyright information in PMC

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