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Meta-Analysis
. 2023 Sep 30;23(1):703.
doi: 10.1186/s12884-023-06006-5.

Impact of maternal psoriasis on adverse maternal and neonatal outcomes: a systematic review and meta-analysis

Shoboo Rahmati  1   2 , Hossein Moameri  1   3 , Neda Malek Mohammadi  1 , Mojtaba Norouzi  1 , Nima Ghalekhani  3 , Amin Beigzadeh  4 , Nasrin Changizi  5 , Hamid Sharifi  6
Affiliations
Meta-Analysis

Impact of maternal psoriasis on adverse maternal and neonatal outcomes: a systematic review and meta-analysis

Shoboo Rahmati et al. BMC Pregnancy Childbirth. .

Abstract

Background: There is a dearth of robust evidence regarding the correlation between psoriasis with maternal and neonatal outcomes, making it challenging to establish definitive recommendations for the management of these patients. This systematic review and meta-analysis aimed to review the evidence with regard to the impact of maternal psoriasis on maternal and neonatal outcomes.

Methods: Following the PRISMA guideline, a systematic search of English articles using PubMed, Embase, Scopus, ScienceDirect, Web of Science, Google Scholar, and the Cochrane Library was conducted. The search was performed from inception to 22nd of May 2022.

Result: A significant association was observed between psoriasis and maternal outcomes, including cesarean delivery [OR = 1.25 (95% CI: 1.13-1.30, p-value = 0.001)], (pre)eclampsia [OR = 1.29 (95% CI: 1.15-1.44, p-value = 0.0001)], gestational diabetes [Odds Ratio (OR) = 1.23 (95% Confidence Intervals (CI): 1.15-1.30, p-value = 0.001)], gestational hypertension [OR = 1.31 (95% CI: 1.18-1.45, p-value = 0.001)] and preterm birth [OR = 1.22 (95% CI: 1.10-1.35, p-value = 0.001)]. Also, there was a significant association between psoriasis and neonatal outcomes, including small for gestational age [OR = 1.07 (95% CI: 1.02-1.11, p-value = 0.053)], low birth weight [OR = 1.19 (95% CI: 1.02-1.38, p-value = 0.001)] and stillbirth [OR = 1.27 (95% CI: 1.04-1.55, p-value = 0.023)].

Conclusion: Maternal psoriasis could negatively impact maternal and neonatal outcomes. Our results strengthen the importance of close monitoring of the mothers' psoriasis status before and during pregnancy.

Keywords: Maternal outcomes; Meta-analysis; Neonatal outcomes; Psoriasis; Psoriatic arthritis.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
A flow chart depicting the stages of retrieving articles and checking eligibility criteria for meta-analysis to assess the impact of psoriasis on pregnancy and neonatal outcomes
Fig. 2
Fig. 2
Geographical distribution of included studies on the impact of psoriasis on maternal and neonatal outcomes
Fig. 3
Fig. 3
Impact of psoriasis on maternal outcomes (Caesarean delivery and Preeclampsia)
Fig. 4
Fig. 4
Impact of psoriasis on maternal outcomes (Gestational diabetes, Gestational hypertension and Preterm birth)
Fig. 5
Fig. 5
Impact of psoriasis on neonatal outcomes (Small for gestational age and Low birth weight)
Fig. 6
Fig. 6
Impact of psoriasis on neonatal outcomes (Stillbirth, Congenital malformations, and Apgar score < 7)
See this image and copyright information in PMC

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