Metabolic regulation of aged hematopoietic stem cells: key players and mechanisms

Nazanin Karimnia¹, James Harris², Shen Y Heazlewood¹, Benjamin Cao³, Susan K Nilsson⁴

Affiliations

¹ Biomedical Manufacturing, Commonwealth Scientific and Industrial Research Organisation, Clayton, Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, Australia.
² Biomedical Manufacturing, Commonwealth Scientific and Industrial Research Organisation, Clayton, Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, Australia; School of Clinical Sciences, Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.
³ Biomedical Manufacturing, Commonwealth Scientific and Industrial Research Organisation, Clayton, Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, Australia. Electronic address: ben.cao@csiro.au.
⁴ Biomedical Manufacturing, Commonwealth Scientific and Industrial Research Organisation, Clayton, Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, Australia. Electronic address: susie.nilsson@csiro.au.

PMID: 37778498
DOI: 10.1016/j.exphem.2023.09.006

Free article

Comment

Metabolic regulation of aged hematopoietic stem cells: key players and mechanisms

Nazanin Karimnia et al. Exp Hematol. 2023 Dec.

Free article

. 2023 Dec:128:2-9.

doi: 10.1016/j.exphem.2023.09.006. Epub 2023 Sep 29.

Authors

Nazanin Karimnia¹, James Harris², Shen Y Heazlewood¹, Benjamin Cao³, Susan K Nilsson⁴

Affiliations

¹ Biomedical Manufacturing, Commonwealth Scientific and Industrial Research Organisation, Clayton, Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, Australia.
² Biomedical Manufacturing, Commonwealth Scientific and Industrial Research Organisation, Clayton, Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, Australia; School of Clinical Sciences, Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.
³ Biomedical Manufacturing, Commonwealth Scientific and Industrial Research Organisation, Clayton, Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, Australia. Electronic address: ben.cao@csiro.au.
⁴ Biomedical Manufacturing, Commonwealth Scientific and Industrial Research Organisation, Clayton, Australia; Australian Regenerative Medicine Institute, Monash University, Clayton, Australia. Electronic address: susie.nilsson@csiro.au.

PMID: 37778498
DOI: 10.1016/j.exphem.2023.09.006

No abstract available

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Conflict of interest statement

Conflict of Interest Disclosure The authors do not have any conflicts of interest to declare in relation to this work.

Comment in

Editorial: Metabolic control in hematopoietic homeostasis, Edited by Keisuke Ito.
Keisuke DI. Keisuke DI. Exp Hematol. 2023 Dec;128:1. doi: 10.1016/j.exphem.2023.11.001. Epub 2023 Nov 4. Exp Hematol. 2023. PMID: 37931774 No abstract available.

Comment on

Mitochondrial Contributions to Hematopoietic Stem Cell Aging.
Morganti C, Ito K. Morganti C, et al. Int J Mol Sci. 2021 Oct 15;22(20):11117. doi: 10.3390/ijms222011117. Int J Mol Sci. 2021. PMID: 34681777 Free PMC article. Review.

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Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities.
Liao Y, Octaviani S, Tian Z, Wang SR, Huang C, Huang J. Liao Y, et al. Stem Cell Res Ther. 2025 Apr 15;16(1):180. doi: 10.1186/s13287-025-04304-7. Stem Cell Res Ther. 2025. PMID: 40234908 Free PMC article. Review.

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Metabolic regulation of aged hematopoietic stem cells: key players and mechanisms

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Metabolic regulation of aged hematopoietic stem cells: key players and mechanisms

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