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Case Reports
. 2023 Aug 30;15(8):e44360.
doi: 10.7759/cureus.44360. eCollection 2023 Aug.

Cytomegalovirus and Epstein-Barr Virus Co-infection in a Patient With Chronic Granulomatous Disease Co-existing With Familial Mediterranean Fever and Early-Onset Inflammatory Bowel Disease: A Case Report

Yazan O Al Zu'bi  1 , Ahmed H Al Sharie  2 , Suleimman Al-Sweedan  1 , Sohaib Al-Khatib  2 , Saied A Jaradat  3 , Eyad Al Tamimi  4
Affiliations
Case Reports

Cytomegalovirus and Epstein-Barr Virus Co-infection in a Patient With Chronic Granulomatous Disease Co-existing With Familial Mediterranean Fever and Early-Onset Inflammatory Bowel Disease: A Case Report

Yazan O Al Zu'bi et al. Cureus. .

Abstract

The association between primary immunodeficiencies and autoinflammatory disorders has been popularized over the past decade. In this report, we illustrated the co-infection of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in a three-year-old Jordanian male patient with an extremely rare variant of the CYBB gene (c.125C>G, p.Thr42Arg) associated with chronic granulomatous disease (CGD) coexisting with familial Mediterranean fever (FMF). CGD and FMF co-existence induced early-onset inflammatory bowel disease mainly resembling Crohn's disease.

Keywords: chronic granulomatous disease; cmv; early onset inflammatory bowel disease; ebv; familial mediterranean fever.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Duodenal mucosa with focal blunting of villous architecture with increase in intraepithelial lymphocytes (30L/100 enterocytes) (A, B) and the lamina propria shows increase in neutrophils and cryptitis (C, D, E). Colon mucosa with preserved crypt architecture and no significant pathologic changes (F).
Figure 2
Figure 2. Family pedigree.
CGD: chronic granulomatous disease; FMF: familial Mediterranean fever
Figure 3
Figure 3. Sanger sequencing chromatogram of the CYBB gene.
See this image and copyright information in PMC

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