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. 2022 Mar 10;1(2):43-50.
doi: 10.1016/j.jacig.2022.02.003. eCollection 2022 May.

Maternal BMI and allergy in children until 3 years of age (JECS)

Daisuke Hayashi  1   2   3 , Emiko Noguchi  1   2 , Kazushi Maruo  4 , Monami Hara  1   2   5 , Shoji F Nakayama  1 , Hidetoshi Takada  5   6 ; Japan Environment and Children’s Study Group
Collaborators, Affiliations

Maternal BMI and allergy in children until 3 years of age (JECS)

Daisuke Hayashi et al. J Allergy Clin Immunol Glob. .

Abstract

Background: Maternal prepregnancy body mass index (BMI) may influence allergic diseases in the children who are the product of those pregnancies.

Objective: The purpose of our study was to investigate the association between mothers' prepregnancy BMI and the risk of physician-diagnosed asthma, food allergy (FA), and atopic dermatitis (AD) in their children during the first 3 years of life.

Methods: Data on mothers' prepregnancy BMI and physician-diagnosed asthma, FA, and AD in their children until the age of 3 years were obtained from the Japan Environment and Children's Study, a nationwide birth cohort study that has recruited 103,099 pregnant women between 2011 and 2014. Logistic regression analysis was used to analyze the results.

Results: We analyzed 67,204 mother-child pairs with available information on physician-diagnosed allergic diseases. The risk of asthma was significantly higher in children born to overweight mothers (adjusted OR [aOR] =1.17 [95% CI = 1.07-1.28]) and obese mothers (aOR = 1.28 [95% CI = 1.08-1.50]), whereas the risk of FA, cow's milk allergy, and egg allergy decreased significantly in children born to overweight mothers (aOR = 0.84 [95% CI = 0.76-0.92]; aOR = 0.78 [95% CI = 0.64-0.93]; and aOR = 0.83 [95% CI = 0.74-0.94]) and obese mothers (aOR = 0.81 [95% CI = 0.67-0.97]; aOR = 0.58 [95% CI = 0.36-0.87]; and aOR = 0.73 [95% CI = 0.56-0.93]) compared with in children born to normal weight mothers, respectively. Associations between AD and maternal BMI were not detected.

Conclusion: Our study showed that an increase in mothers' prepregnancy BMI was associated with an increase in asthma prevalence and a decrease in FA prevalence in their children. Further studies are needed to reveal the mechanisms associated with maternal BMI and pediatric allergic diseases.

Keywords: Atopic dermatitis; asthma; cow’s milk allergy; egg allergy; food allergy; prepregnancy maternal body mass index.

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Figures

Fig 1
Fig 1
Flow diagram of the study.
Fig 2
Fig 2
Relationship between mothers' prepregnancy BMI and allergic disease in their children without adjustment. †P < .05; ‡P < .001.
Fig 3
Fig 3
Relationship between maternal BMI and FA in the children, adjusted with cofounding factors (model 1). Adjusted for maternal age, smoking in pregnancy, maternal allergic diseases, child’s sex, and maternal education. †P < .05; ‡P < .001.
Fig 4
Fig 4
Relationship of maternal BMI and FA in the children to child feeding pattern (model 2) Adjusted for maternal age, smoking in pregnancy, maternal allergic diseases, child’s sex, maternal education, formula feeding at 1 month after birth, and feeding of complementary food at 6 months after birth. †P < .05; ‡P < .001.
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References

    1. Cook-Mills J.M. Maternal influences over offspring allergic responses. Curr Allergy Asthma Rep. 2015;15:501. - PMC - PubMed
    1. Litonjua A.A., Carey V.J., Burge H.A., Weiss S.T., Gold D.R. Parental history and the risk for childhood asthma. Does mother confer more risk than father? Am J Respir Crit Care Med. 1998;158:176–181. - PubMed
    1. Böhme M., Wickman M., Lennart Nordvall S., Svartengren M., Wahlgren C.F. Family history and risk of atopic dermatitis in children up to 4 years. Clin Exp Allergy. 2003;33:1226–1231. - PubMed
    1. van Esch B., Porbahaie M., Abbring S., Garssen J., Potaczek D.P., Savelkoul H.F.J., et al. The impact of milk and its components on epigenetic programming of immune function in early life and beyond: implications for allergy and asthma. Front Immunol. 2020;11:2141. - PMC - PubMed
    1. Acevedo N., Alashkar Alhamwe B., Caraballo L., Ding M., Ferrante A., Garn H., et al. Perinatal and early-life nutrition, epigenetics, and allergy. Nutrients. 2021;13:724. - PMC - PubMed

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