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Review
. 2022 Apr 9;1(2):27-36.
doi: 10.1016/j.jacig.2022.04.001. eCollection 2022 May.

Novel potential treatable traits in asthma: Where is the research taking us?

Affiliations
Review

Novel potential treatable traits in asthma: Where is the research taking us?

Tara F Carr et al. J Allergy Clin Immunol Glob. .

Abstract

Asthma is a complex, heterogeneous disease in which the underlying mechanisms are not fully understood. Patients are often grouped into phenotypes (based on clinical, biologic, and physiologic characteristics) and endotypes (based on distinct genetic or molecular mechanisms). Recently, patients with asthma have been broadly split into 2 phenotypes based on their levels of type 2 inflammation: type 2 and non-type 2 asthma. However, this approach is likely oversimplified, and our understanding of the non-type 2 mechanisms in asthma remains extremely limited. A better understanding of asthma phenotypes and endotypes may assist in development of drugs for new therapeutic targets in asthma. One approach is to identify "treatable traits," which are specific patient characteristics related to phenotypes and endotypes that can be targeted by therapies. This review will focus on emerging treatable traits in asthma and aim to describe novel patient subgroups and endotypes that may represent the next step in the search for new therapeutic approaches.

Keywords: Asthma; airway remodeling; infection-mediated; inflammation; phenotype; physiologic; trait; treatable.

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Figures

Fig 1
Fig 1
Novel treatable traits in asthma. An overview of the inflammatory, physiologic, and infection-mediated treatable traits for asthma, their potential mechanistic targets, and potential treatment classes. Feno, Fractional exhaled nitric oxide; ISG, interferon-stimulated gene; TCR, T-cell receptor.

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