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Meta-Analysis
. 2023 Sep 13:14:1216962.
doi: 10.3389/fendo.2023.1216962. eCollection 2023.

Effects of concurrent aerobic and resistance training on vascular health in type 2 diabetes: a systematic review and meta-analysis

Shengju Chen  1 , Kaixiang Zhou  2 , Huayu Shang  3 , Mingyang Du  4 , Linfeng Wu  4 , Yu Chen  4
Affiliations
Meta-Analysis

Effects of concurrent aerobic and resistance training on vascular health in type 2 diabetes: a systematic review and meta-analysis

Shengju Chen et al. Front Endocrinol (Lausanne). .

Abstract

Objective: To determine the impacts of concurrent aerobic and resistance training on vascular structure (IMT) and function (PWV, FMD, NMD) in type 2 diabetes (T2D).

Methods: The electronic databases PubMed, Web of Science Core Collection, Cochrane Library, Embase, Scopus, CINAHL, and SPORTDiscus were systematically searched for articles on "type 2 diabetes" and "concurrent training" published from inception to August 2, 2022. We included randomized controlled trials that examined the effects of concurrent training versus passive controls on IMT, PWV, FMD and NMD in T2D.

Results: Ten studies were eligible, including a total of 361 participants. For IMT, concurrent training showed a slight decrease by 0.05 mm (95% CI -0.11 to 0.01, p > 0.05). concurrent training induced an overall significant improvement in FMD by 1.47% (95% CI 0.15 to 2.79, p < 0.05) and PWV by 0.66 m/s (95% CI -0.89 to -0.43, p < 0.01) in type 2 diabetics. However, concurrent training seemed to exaggerate the impaired NMD (WMD = -2.30%, 95% CI -4.02 to -0.58, p < 0.05).

Conclusions: Concurrent training is an effective method to improve endothelial function and artery stiffness in T2D. However, within 24 weeks concurrent training exacerbates vascular smooth muscle dysfunction. More research is needed to explore whether longer and/or higher-intensity concurrent training interventions could enhance the vascular structure and smooth muscle function in this population.

Systematic review registration: www.crd.york.ac.uk/PROSPERO/, identifier CRD42022350604.

Keywords: aerobic and resistance training; concurrent training; type 2 diabetes; vascular function; vascular structure.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1
Figure 1
PRISM flow chart illustrating the different phases of the search and study selection. PRISMA Preferred Reporting Items for Systematic Reviews and Meta-Analysis.
Figure 2
Figure 2
Risk of bias assessment.
Figure 3
Figure 3
Pooled effects of CT groups vs. control groups on changes in vascular structure and function: (A) vascular structure index (IMT); (B) vascular function index (PWV); (C) vascular function index (FMD); (D) vascular function index (NMD). The squares represent the mean difference for each trial. The diamond represents the pooled mean difference across all trials. a represents cf PWV, b represents cd PWV, c represents cr PWV.
See this image and copyright information in PMC

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