Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Sep 14:17:1233499.
doi: 10.3389/fnhum.2023.1233499. eCollection 2023.

Evaluation of consciousness rehabilitation via neuroimaging methods

Jianyang Wang  1 , Xinyu Gao  1 , Zuchao Xiang  1 , Fangfang Sun  1 , Yong Yang  1
Affiliations
Review

Evaluation of consciousness rehabilitation via neuroimaging methods

Jianyang Wang et al. Front Hum Neurosci. .

Abstract

Accurate evaluation of patients with disorders of consciousness (DoC) is crucial for personalized treatment. However, misdiagnosis remains a serious issue. Neuroimaging methods could observe the conscious activity in patients who have no evidence of consciousness in behavior, and provide objective and quantitative indexes to assist doctors in their diagnosis. In the review, we discussed the current research based on the evaluation of consciousness rehabilitation after DoC using EEG, fMRI, PET, and fNIRS, as well as the advantages and limitations of each method. Nowadays single-modal neuroimaging can no longer meet the researchers` demand. Considering both spatial and temporal resolution, recent studies have attempted to focus on the multi-modal method which can enhance the capability of neuroimaging methods in the evaluation of DoC. As neuroimaging devices become wireless, integrated, and portable, multi-modal neuroimaging methods will drive new advancements in brain science research.

Keywords: EEG; PET; disorders of consciousness; fMRI; fNIRS; multimodal.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Various neuroimaging methods.
Figure 2
Figure 2
Flow chart of study selection process.
Figure 3
Figure 3
EEG acquisition and analysis.
Figure 4
Figure 4
Principle of resting-state and task-based fMRI.
Figure 5
Figure 5
Frequency-domain and time-domain fNIRS.
Figure 6
Figure 6
Multimodal study based on PET and MRI.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Abdalmalak A., Milej D., Norton L., Debicki D. B., Owen A. M., St K., et al. . (2021). The potential role of FNIRS in evaluating levels of consciousness. Front. Hum. Neurosci. 15:703405. doi: 10.3389/fnhum.2021.703405, PMID: - DOI - PMC - PubMed
    1. Amiri M., Fisher P. M., Raimondo F., Sidaros A., Cacic Hribljan M., Othman M. H., et al. . (2023). Multimodal prediction of residual consciousness in the intensive care unit: the CONNECT-ME study. Brain 146, 50–64. doi: 10.1093/brain/awac335, PMID: - DOI - PMC - PubMed
    1. Arico I., Naro A., Pisani L. R., Leo A., Muscara N., De Salvo S., et al. . (2016). Could combined sleep and pain evaluation be useful in the diagnosis of disorders of consciousness (DOC)? Preliminary findings. Brain Inj. 30, 159–163. doi: 10.3109/02699052.2015.1089595, PMID: - DOI - PubMed
    1. Aubinet C., Cassol H., Gosseries O., Bahri M. A., Larroque S. K., Majerus S., et al. . (2020). Brain metabolism but not gray matter volume underlies the presence of language function in the minimally conscious state (MCS): MCS plus versus MCS- neuroimaging differences. Neurorehabil. Neural Repair 34, 172–184. doi: 10.1177/1545968319899914 - DOI - PubMed
    1. Ballanti S., Campagnini S., Liuzzi P., Hakiki B., Scarpino M., Macchi C., et al. . (2022). EEG-based methods for recovery prognosis of patients with disorders of consciousness: a systematic review. Clin. Neurophysiol. 144, 98–114. doi: 10.1016/j.clinph.2022.09.017, PMID: - DOI - PubMed